Results 161 to 170 of about 891,962 (308)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Editorial: Insights in animal behavior and welfare: 2021. [PDF]

Front Vet Sci, 2022
Narayan E.
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

2012 INTERNATIONAL SYMPOSIUM ON ANIMAL BIOTECHNOLOGY, SHINSHU UNIVERSITY

, 2012
Date: January 31, 2012 / Venue: Faculty of Agriculture, Shinshu University / Host: Shinshu UniversitySpecial Lecture: Sarah Marie Cummings / Plenary Lectures: Hiroshi Kagami "Perspectives for Animal Biotechnology" / Plenary Lectures: Koh-ichi Hamano "Sex
INTERNATIONAL SYMPOSIUM ON ANIMAL BIOTECHNOLOGY, SHINSHU UNIVERSITY, INTERNATIONAL, SYMPOSIUM ON ANIMAL BIOTECHNOLOGY, SHINSHU UNIVERSITY   +1 more
core  

Data-driven simulator of multi-animal behavior with unknown dynamics via reinforcement learning. [PDF]

iScience
Fujii K, Tsutsui K, Teshima Y, Itoh M, Takeishi N, Nishiumi N, Tanaka R, Shigaki S, Kawahara Y.   +8 more
europepmc   +1 more source

Integrating remote international experience and community engagement into course-based animal behavior research. [PDF]

Ecol Evol, 2023
Kay AD, Lager Z, Bhebheza L, Heinen-Kay JL.   +3 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Changing minds epigenetically: Germline genes in neurons disrupt animal behavior. [PDF]

Proc Natl Acad Sci U S A
Teets E, Singhvi A.
europepmc   +1 more source

Editorial: Acoustic communication analysis for understanding animal behavior. [PDF]

Front Behav Neurosci, 2022
Bonini SA, Pietropaolo S.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source