Results 81 to 90 of about 2,157,203 (309)
Modelling Agricultural Systems: Applications to Livestock Breeding [PDF]
Traditionally the evaluation of animal genetic traits has focused primarily on production traits and the construction of selection indices. Selection indices, however, fail to consider the effect of management practices and the environment on ...
Hattam, Caroline
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Textbook animal breeding : animal breeding andgenetics for BSc students [PDF]
, 2014 This textbook contains teaching material on animal breeding and genetics for BSc students. The text book started as an initiative of the Dutch Universities for Applied (Agricultural) Sciences.
Oldenbroek, Kor +2 more
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Systems biology in animal sciences [PDF]
, 2011 Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
Pas, M.F.W., te +11 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Journal of animal breeding and genetics
, 2019 Special issue : Statistics, genetics and animal/plant breeding - papers in honour of Robin ...
Thompson, R.
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The feeding and breeding of laboratory animals. VI. The breeding of mice [PDF]
Epidemiology and Infection, 1947 1. The total reproductive performance of two groups each of twenty-four mice over a period of one year under two different systems of mating has been recorded.2. In the first system (monogamous pairs) the male was kept continuously with the female; in 78% of cases the females became pregnant again at post-partum oestrus and were thus subjected for the ...
openaire +2 more sources
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
BMC GenomicsBackground Genomic Best Linear Unbiased Prediction (GBLUP) assumes that all SNPs contribute equally to genetic variance, including those with minimal impact, limiting its accuracy. A major challenge in animal breeding is to develop more scientific models
Weijie Zheng +5 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source