Results 81 to 90 of about 1,256,762 (303)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Bottlenose Dolphins’ Clicks Comply with Three Laws of Efficient Communication

Algorithms
Bottlenose dolphins’ broadband click vocalisations are well-studied in the literature concerning their echolocation function. Their potential use for communication among conspecifics has long been speculated but has yet to be conclusively established. In
Arthur Stepanov, Hristo Zhivomirov, Ivaylo Nedelchev, Todor Ganchev, Penka Stateva   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Library support for an academic medical center's institutional animal care and use committee (IACUC) [PDF]

, 2005
Building a communication network between an academic medical center’s library and its Institutional Animal Care and Use Committee (IACUC) can lead to specialized reference services that aid institutions in meeting the information requirements of the ...
Chilov, Marina, Matsoukas, Konstantina
core   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Quantifying degradation in animal acoustic signals with the R package baRulho

Methods in Ecology and Evolution
Animal acoustic signals are shaped by selection to convey information based on their tempo, intensity, and frequency. However, sound signals degrade as they transmit over space and across physical obstacles (e.g., vegetation or infrastructure), which ...
Marcelo Araya‐Salas, Erin E. Grabarczyk, Marcos Quiroz‐Oliva, Adrián García‐Rodríguez, Alejandro Rico‐Guevara   +4 more
doaj   +1 more source

Signal categorization by foraging animals depends on ecological diversity

eLife, 2019
Warning signals displayed by defended prey are mimicked by both mutualistic (Müllerian) and parasitic (Batesian) species. Yet mimicry is often imperfect: why does selection not improve mimicry?
David William Kikuchi, Anna Dornhaus, Vandana Gopeechund, Thomas N Sherratt   +3 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Animal health of ruminants: A summary of research conducted under the German Federal Programme for Organic Agriculture and other forms of Sustainable Agriculture [PDF]

, 2012
Between 2002 and 2003, a survey established the status quo of organic dairy and beef production. A questionnaire was sent to 750 farms, supplemented by an on-site survey of 100 farms that supplied data on livestock performance, profitability, feeding ...
Anon, AN
core