Results 131 to 140 of about 1,350,044 (307)

A direct computer control concept for mammalian cell fermentation processes

, 1994
Büntemeyer H, Marzahl R, Lehmann J. A direct computer control concept for mammalian cell fermentation processes. Cytotechnology. 1994;15(1-3):271-279.In the last 10 years, new assignments and the special demands of mammalian cells to the culture ...
Lehmann, Jürgen, Büntemeyer, Heino, Marzahl, Rainer   +2 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Human, Animal, and Technology: Multiple Hybridizations In Perceforest

, 2018
In the late Middle Ages, hybrids invade the imaginary space of literature and art. Abnormal bodies of humans with animal features were common in human imagination since at least the Antiquity, but Perceforest, a 14th-century masterpiece of French romance
British Animal Studies Network Meeting "Animal Machines / Machine Animals", Sciancalepore, Antonella   +1 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

In Testing Times: Conducting an Ethnographic Study of UK Animal Rights Protesters [PDF]

This article reflects upon the experience of conducting research into a UK-based, though internationally-renowned, animal rights group. The article firstly rationalizes the ethnographic research methodology used to approach Stop Huntingdon Animal Cruelty
Andrew Upton
core  

Sodium propionate supplementation improves the negative energy balance in postpartum dairy cattle through regulation of glycolipid metabolism

Journal of Integrative Agriculture
The study goal was to determine the effects of sodium propionate (NaPr) during the postpartum period on lactation performance, milk fatty acid (FA) profile, blood metabolites, and fat mobilization.
Maocheng Jiang, Zitong Meng, Dejin Tan, Zhiqiang Cheng, Zhenwu Wei, Miao Lin, Guoqi Zhao, Kang Zhan   +7 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The nature of culture : an eight-grade model for the evolution and expansion of cultural capacities in hominins and other animals

, 2015
Tracing the evolution of human culture through time is arguably one of the most controversial and complex scholarly endeavors, and a broad evolutionary analysis of how symbolic, linguistic, and cultural capacities emerged and developed in our species is ...
Collard, Mark, Haidle, Miriam Noël, Conard, N., Tennie, Claudio, Bolus, M., Whiten, A., Haidle, M.N., Nowell, April, Haidle, M., Nowell, A., Lombard, Marlize, Haidle, Miriam, Tennie, C., Collard, M., Tennie, C. ; https://orcid.org/, Bolus, Michael, Whiten, Andrew, Garofoli, D., Garafoli, Duilio, Garofoli, Duilio, Conard, N.J., Conard, Nicholas, Lombard, M.   +22 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source