Results 51 to 60 of about 1,479,401 (263)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Extended Human-to-Human Transmission during a Monkeypox Outbreak in the Democratic Republic of the Congo

open access: yesEmerging Infectious Diseases, 2016
A >600% increase in monkeypox cases occurred in the Bokungu Health Zone of the Democratic Republic of the Congo during the second half of 2013; this increase prompted an outbreak investigation. A total of 104 possible cases were reported from this health
Leisha Diane Nolen   +23 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The synonymy in English terminological field of “animal diseases”

open access: yesStudia Humanitatis, 2020
The article considers the study of the synonymy phenomenon in English terminological field of “animal diseases”. The author highlights and analyses the main types of synonymy in the examined terminology and characterises structural features of ...
Rozhkov Yuriy Hryhorevych
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Other animal prion diseases [PDF]

open access: yesBritish Medical Bulletin, 2003
In addition to bovine spongiform encephalopathy (BSE) of cattle and scrapie of sheep and goats, a few other animal prion diseases have been reported. These include feline spongiform encephalopathy of zoological and domestic cats (FSE) and transmissible spongiform encephalopathy (TSE) of zoological ruminants and non-human primates, as well as chronic ...
Christina J, Sigurdson   +1 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Advances in Animal Disease Surveillance and Information Systems and Their Role in Disease Control and Prevention: Implications in Ethiopia

open access: yesVeterinary Medicine and Science
Background Animal disease surveillance and information systems enable early disease detection, monitoring of endemic diseases, identification of emerging diseases and timely control of diseases having serious impacts on animal health, public health and ...
Aweke Engdawork, Haileleul Negussie
doaj   +1 more source

Prevalence of Batrachochytrium dendrobatidis in Amphibians in Northwestern Italy’s Protected Areas

open access: yesAnimals
Chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), is a significant threat to global amphibian populations, leading to widespread declines and extinctions.
Arianna Meletiadis   +7 more
doaj   +1 more source

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