Results 191 to 200 of about 377,815 (340)

3R centres contributions to change animal experimentation : A field report from Charité 3^R, the 3R centre of a medical faculty. [PDF]

EMBO Rep
Retter I, Behm L, Grohmann L, Schmelz K, Rosowski J, Hippenstiel S.   +5 more
europepmc   +1 more source

Animal Models and Animal Experimentation in the Development of Deep Brain Stimulation: From a Specific Controversy to a Multidimensional Debate. [PDF]

Front Neuroanat, 2019
Desmoulin-Canselier S, Moutaud B.
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Animal Experimentation and Animal Welfare in the Context of the European Union: Reflections on the Directive 2010/63/EU and Its Transposition in Italy

, 2015
Ilja Richard Pavone
openalex   +1 more source

Applying the Three Rs to Animal Experimentation and Animal Testing: Are We Merely Drifting or Lying at Anchor? [PDF]

, 2006
Michael Balls, Robert D. Combes
openalex   +1 more source

Face Transplantation [PDF]

, 2008

core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The flaws and human harms of animal experimentation. [PDF]

Camb Q Healthc Ethics, 2015
Akhtar A.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Perspectives of FTIR as Promising Tool for Pathogen Diagnosis, Sanitary and Welfare Monitoring in Animal Experimentation Models: A Review Based on Pertinent Literature. [PDF]

Microorganisms
Neves MM, Guerra RF, de Lima IL, Arrais TS, Guevara-Vega M, Ferreira FB, Rosa RB, Vieira MS, Fonseca BB, Sabino da Silva R, Silva MVD.   +10 more
europepmc   +1 more source