Results 221 to 230 of about 2,045,746 (251)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Soaring Systematics: An Evaluation of Biogeography and Flight Behavior in Dragonflies and Damselflies (Insecta: Odonata) Using Phylogenomics. [PDF]

Syst Biol
Newton LG, Abbott JC, Bybee SM, Carter P, Frandsen PB, Goodman A, Guralnick R, Hahn B, Idec J, Kalkman VJ, Kolhi M, Fomekong-Lontchi J, Lupiyaningdyah P, Onsongo V, Rowe E, Sanchez-Herrera M, Pinkert S, Sutherland L, Tolman E, Uche-Dike R, Barden P, Belitz M, Bota-Sierra CA, Cordero-Rivera A, Córdoba-Aguilar A, Dijkstra KB, Dow RA, Ehlert J, Ferreira RG, Hämäläinen M, Juen L, Lorenzo-Carballa MO, Mauffray B, Nielsen AL, Pessacq P, Pham TH, Pinto ÂP, Richards SJ, Salas R, Skevington JH, Theischinger G, Zhang H, Ware JL.   +42 more
europepmc   +1 more source

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

A hierarchical navigation decision-making method for UAV swarms in unknown communication-constrained environments. [PDF]

PLoS One
Xiong H, Yu B, Zhang J, Dong H.
europepmc   +1 more source

Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota

Advanced Science, EarlyView.
Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal, Ronald Garcia, Guangyi Chen, Chantal D. Bader, Peter Sullivan, Alexander Popoff, Daniel Krug, Maja Hunter, Sebastian Walesch, Emilia Oueis, Christine Frank, Haowen Zhao, Joachim J. Hug, Sebastian Keller, Pascal Hirsch, Azat Tagirdzhanov, Tatiana Malygina, Mary Victory E. Gutierrez, Alexey Gurevich, Judith Boldt, Boyke Bunk, Jörg Overmann, Ulrich Nübel, Andreas Keller, Olga V. Kalinina, Rolf Müller   +25 more
wiley   +1 more source

Odor tracking in flying <i>Drosophila</i> requires visual reafference and compass neurons. [PDF]

Proc Natl Acad Sci U S A
Paul Currea J, Bignell AE, Rieke-Wey I, Limbania D, Duistermars BJ, Wasserman SM, Frye MA.   +6 more
europepmc   +1 more source

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source

Advances in mosquito olfaction: Genetic, genomic, and behavioral approaches in Aedes aegypti. [PDF]

Curr Opin Neurobiol
Hill TJ, Kohli G, Younger MA.
europepmc   +1 more source

A stereo dataset of annotated budgerigar flight trajectories for multi-agent collision avoidance studies. [PDF]

Data Brief
Tawhid SM, Mohim AK, Ali SS, Tanzil KTH, Nandi D, Bhowmik A, Karmaker D.   +6 more
europepmc   +1 more source

Potential entry pathways for 25 vector-borne disease agents. [PDF]

EFSA J
European Food Safety Authority (EFSA), Dhollander S, Baltusyte I, Bigoni F, Broglia A, Figuerola J, Thulke HH, Chueca Miranda MA.   +7 more
europepmc   +1 more source