Results 161 to 170 of about 4,555,463 (303)

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Analysis of transmission effect of digital economy on new quality productivity of livestock industry——Based on panel data from 30 provinces

Siliao yanjiu
This study aims to explore in depth the impact of the digital economy on the new quality productivity of animal husbandry, and examine whether green technology innovation is the pathway through which the digital economy affects the new quality ...
LIU Yumeng
doaj  

Mitigating antimicrobial resistance in the animal industry: reduction strategies and alternatives to antibiotics. [PDF]

Front Vet Sci
Al-Khalaifah H, Al-Surrayai T.
europepmc   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Molecular Detection and Genomic Characterization of Porcine Enterovirus G in Guangxi, China: Genotype Diversity, PLCP Insertions, and Recombination. [PDF]

Viruses
Jiang K, Li B, Wu X, Zhao W, Qin Y, Zhao S, Chen Z, Wang W, Duan Q, Zhou Y, Quan C, Xu X, Chen T, Xu Y, Su H, Yang X, Qin Y, Peng Y, He Y, Lu B.   +19 more
europepmc   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Study on spatial agglomeration characteristics and influencing factors of the modernization development of animal husbandry in China

Siliao yanjiu
Based on the panel data of 31 provinces in China from 2008 to 2022, this paper uses geographical concentration degree and spatial Gini coefficient to explore the spatial agglomeration characteristics of Chinese livestock modernization development, and ...
GAO Jian
doaj  

Identification of key candidate genes for body weight traits in male Dongfeng sika deer based on genome-wide association analysis. [PDF]

Sci Rep
Zhang X, Zhang Y, Zhao L, Zhao Y, Qian WX, Gai G, Song J, Du P, Han H, Zhang Z.   +9 more
europepmc   +1 more source

The Plant‐to‐Plant Circular Strategy: Coupling Photodegradation and Phytoremediation With Plant‐Based Nanomaterials for Plastic Degradation

Advanced Science, EarlyView.
Plant‐based nanomaterials derived from alfalfa serve as dual‐function catalysts, coupling photodegradation and phytoremediation to degrade polyethylene under UV‐A light and in soil. The nanomaterials work synergistically with alfalfa and soil microbes, achieving efficient plastic breakdown without trophic transfer.
Haoran Liu, Lena Ciric, Yuheng Wang, Ziru Pei, Manpreet Bhatti   +4 more
wiley   +1 more source

TaqMan-probe-based multiplex real-time qPCR assay for simultaneous detection of Duck Tembusu virus, Novel duck reovirus, and Duck circovirus. [PDF]

Front Microbiol
Wang Z, Xi H, Tan J, Lin C, Gao X, Wang S, Li H, Guo X.   +7 more
europepmc   +1 more source