Results 91 to 100 of about 26,422,673 (403)
Capping Enzyme mRNA-cap/RNGTT Regulates Hedgehog Pathway Activity by Antagonizing Protein Kinase A
Scientific Reports, 2017 Hedgehog (Hh) signaling plays a pivotal role in animal development and its deregulation in humans causes birth defects and several types of cancer. Protein Kinase A (PKA) modulates Hh signaling activity through phosphorylating the transcription factor ...
Ping Chen +7 more
doaj +1 more source
Laboratory Animal Research, 2022 Background Rheumatoid arthritis (RA) is a chronic inflammatory disease of joint, but there is no known cure. 3′-sialyllactose (3′-SL) is an oligosaccharide that is abundant in breast milk of mammals, and has anti-inflammatory properties.
Young June Kim +6 more
doaj +1 more source
A method for estimating the distribution of species susceptible to foot-and-mouth disease in the Kruger National Park Region [PDF]
, 2007 Landscape distribution of susceptible species is needed to model the spatial spread of infectious diseases. Our objective is to develop 2 individual species animal count maps - for African buffalo and domestic cattle susceptible to foot-and-mouth disease
Brahmbhatt, Dipa P. +8 more
core
, 2006 In 2002–2003, severe acute respiratory syndrome (SARS) was a newly identified illness that emerged in Southern China, spread to involve more than 30 countries, and affected more than 8000 people and caused nearly 800 deaths worldwide. Although the etiologic agent was rapidly identified to be a previously unknown coronavirus (named SARS coronavirus or ...
Kanta Subbarao, Anjeanette Roberts
openaire +3 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Combinatorial Control of Recruitment of a Variant PRC1.6 Complex in Embryonic Stem Cells
Cell Reports, 2018 Summary: Though genetic data suggest that Polycomb group proteins (PcGs) are central chromatin modifiers and repressors that have been implicated in control of embryonic stem cell (ESC) pluripotency, the precise mechanism of PcG complex recruitment ...
Yikai Huang +8 more
doaj
Generation of rat offspring from ovarian oocytes by xenotransplantation
Scientific ReportsThe idea of utilizing unused oocytes present in the ovaries has been tested in various ways to produce offspring. However, only a limited number of studies succeeded in offspring generation.
Hiroaki Taketsuru +6 more
doaj +1 more source
EBioMedicine, 2020 Background: Alteration of commensal bacterial composition is associated with many inflammatory diseases. However, few studies have pinpointed the specific bacterial genes that may suppress host immune responses against microbes and maintain homeostasis ...
Dayuan Zou +14 more
doaj
Loss of endothelial EMCN drives tumor lung metastasis through the premetastatic niche
Journal of Translational Medicine, 2022 Background Metastasis is the primary cause of cancer-related mortality. Metastasis involves a complex multistep process during which individual tumor cells spread primarily through destruction of the endothelial barrier, entering the circulatory system ...
Guoxin Zhang +5 more
doaj +1 more source
Endocrine-Related Cancer, 2017 Animal models of cancer have been instrumental in advancing our understanding of the biology of tumor initiation and progression, in studying gene function and in performing preclinical studies aimed at testing novel therapies. Several animal models of the MEN1 syndrome have been generated in different organisms by introducing loss-of-function ...
Mohr H., Pellegata N. S.
openaire +5 more sources