Results 271 to 280 of about 27,467,558 (397)

Comprehensive analysis of polymethoxyflavone metabolism in orange peel using an animal model. [PDF]

RSC Adv
An JP, Liu X, Kim D, Madden R, Wang Y.
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Endogenous animal spirits and investment an agent-based model [PDF]

Fontana Magda, Marchionatti Roberto
core  

A whole farm-model to simulate the environtnental impacts of animal farming systems: MELODIE [PDF]

, 2009
Baratte, C., Chardon, X., Delaby, Luc, Dourmad, Jean-Yves, Espagnol, Sandrine, Faverdin, Philippe, Le Gall, A., Leterme, Philippe, Martin-Clouaire, Roger, Morvan, Thierry, Paillat, Jean-Marie, Poupa, J.C., Raison, C., Rellier, Jean-Pierre, Rigolot, C.   +14 more
core  

(P23) collagen fleece grafting of the tunica albuginea in animal models: does size matter? [PDF]

Raouf M. Seyam, Turki O. Alhussain, Said A Kattan, Waleed M. Altaweel   +3 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Assessing progesterone receptor modulation in glioblastoma: from <i>in vitro</i> and animal model to a human pilot protocol. [PDF]

Cancer Biol Ther
Arcos-Montoya D, García-López P, Wegman-Ostrosky T, Camacho-Arroyo I, Valdés-Rives SA, Bello-Alvarez C, Manjarrez-Marmolejo J, De La Fuente-Granada M, Ordaz-Ramos A, Ávila-González D, Díaz NF, Guadarrama-Rangel CF, Navarrete AMB, Aboud O, Cantú-de-León DF, Cacho-Díaz B, González-Arenas A.   +16 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Correction: TSG101 depletion dysregulates mitochondria and PML NBs, triggering MAD2-overexpressing interphase cell death (MOID) through AIFM1-PML-DAXX pathway

Cell Death and Disease
Yao Xi, Rui Xu, Shengnan Chen, Jiezhu Fang, Xiang Duan, Yidan Zhang, Guoli Zhong, Zhifei He, Yan Guo, Xinyu Li, Wenzhi Tao, Yang Li, Yan Li, Lei Fang, Yohei Niikura   +14 more
doaj   +1 more source