Results 291 to 300 of about 27,467,558 (397)

Utilizing biomaterials for laryngeal respiratory mucosal tissue repair in an animal model. [PDF]

Biomater Biosyst
Salary M, Mohebbi S, Ahmadi A, Bagher Z, Pezeshki-Modaress M, Aminianfar H, Farzad-Mohajeri S, Samiei N, Taghizadeh-Hesary F, Ghanbari H.   +9 more
europepmc   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Establishment of a patient-derived drug-resistant oral squamous cell carcinoma animal model. [PDF]

Animal Model Exp Med
Feng C, Liu H, Lu Y, Xu Y, Wu X, Wang J, Qin C, Li B, Li Y.   +8 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

TSPO Modulation Prevents Photoreceptor Degeneration and Produces Neuroprotective Effects in an Animal Model of Retinitis Pigmentosa. [PDF]

Cells
Corsi F, Castagnoli J, Galante A, Fabiano A, Nuti E, Piras AM, Taliani S, Piano I, Gargini C.   +8 more
europepmc   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Data mining-based analysis to explore the application of an animal model of diabetic gastroparesis. [PDF]

Front Endocrinol (Lausanne)
Xu H, Miao FR, He YJ, Fan YS.
europepmc   +1 more source

Investigating the role of Neuropeptide Y infusions to the dorsal hippocampus in mediating behaviour in several animal models of anxiety

, 2014
Charelle O'Dunn-Orto
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source