Results 291 to 300 of about 3,851,825 (350)

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Dynamics of oxylipin biosynthesis in systemic inflammation: insights from a large animal model of endotoxemia. [PDF]

Front Immunol
Myers MN, Chirivi M, Dos Santos Neto JM, Parales-Girón J, Worden LC, Lock AL, Contreras GA.   +6 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

The Chicken Embryo: An Alternative Animal Model in Development, Disease and Pharmacological Treatment. [PDF]

Pharmacol Res Perspect
Kaplan-Arabaci O, Dančišinová Z, Paulsen RE.   +2 more
europepmc   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

FEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

Combined Oxaliplatin with 5-Fluorouracil for Effective Chemotherapy Against Gastric Cancer in Animal Model. [PDF]

Int J Nanomedicine
Ren J, Song M, Ding D, Lan T, Li Y, Liang R, Huang S, Jiang G, You J, Yang J, Chen C, Luan W, Abdullaev B, Huang H, Zhao Y, Wei B.   +15 more
europepmc   +1 more source

The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer's disease animal model. [PDF]

Open Vet J
Titisari N, Ahmad H, Samsulrizal N, Fauzi A, Abdul Razak IS.   +4 more
europepmc   +1 more source