Results 291 to 300 of about 27,577,089 (399)

Effects of maternal BMI on early pregnancy endocrine-metabolic function and offspring development: Evidence from a retrospective cohort and animal model. [PDF]

PLoS One
Shen W, Niu A, Zhang Q, Deng J, Xu X, Ma X, Zhao H, Lou Y.   +7 more
europepmc   +1 more source

Endogenous animal spirits and investment an agent-based model [PDF]

Fontana Magda, Marchionatti Roberto
core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Analysis of Scyllo-Inositol in a Wistar Rat Animal Model-A Preliminary Study. [PDF]

Pharmaceuticals (Basel)
Wiśniewski K, Zglejc-Waszak K, Antonowski T, Szablinska-Piernik J, Juskiewicz J, Lahuta L, Jozwik M, Wojtkiewicz J.   +7 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Assessing progesterone receptor modulation in glioblastoma: from <i>in vitro</i> and animal model to a human pilot protocol. [PDF]

Cancer Biol Ther
Arcos-Montoya D, García-López P, Wegman-Ostrosky T, Camacho-Arroyo I, Valdés-Rives SA, Bello-Alvarez C, Manjarrez-Marmolejo J, De La Fuente-Granada M, Ordaz-Ramos A, Ávila-González D, Díaz NF, Guadarrama-Rangel CF, Navarrete AMB, Aboud O, Cantú-de-León DF, Cacho-Díaz B, González-Arenas A.   +16 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Melanophilin knockout chicken, as a new alopecia animal model. [PDF]

Poult Sci
Kim DH, Lee J, Choi W, Lee K.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source