Results 121 to 130 of about 3,236,415 (311)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Characterisation of small ruminant production in Crete [PDF]

, 2011
Subproject 2 of the LowInputBreeds project aims to improve performance, animal health & welfare, and product quality in organic and low input breed sheep production systems.
Smaragda, Sotiraki, Stefanakis, Alexandros   +1 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Development of an advisory system that supports good animal welfare in organic production in Norway [PDF]

, 2004
Organic agriculture wishes to emphasise animal welfare, and aims to be at the forefront with regard to promoting the welfare of farm animals. It is therefore important to increase the expertise in the field of animal welfare in organic farming systems ...
Henriksen, Britt I. F.
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Epidemiology of Cysticercus tenuicollis in Sheep and Goats in the Tropics: A Systematic Review

Veterinary Medicine International
Sheep and goat influence the socioeconomic sustainability of rural communities in tropical countries, but parasitic diseases and Cysticercus tenuicollis in particular are responsible for their low productivity.
Prudentia Yensi Lawan, Aziwo Tatanja Niba, Julius Awah-Ndukum   +2 more
doaj   +1 more source

Association of CYP2A6 gene related to the characteristic carcass, commercial cuts, quality of meat and cholesterol of lamb meat

Journal of the Indonesian Tropical Animal Agriculture
As meat-producing livestock, sheep are a benchmark for communities seeking quality and healthy meat. The CYP2A6 gene has emerged as a potential tool for improving lamb meat quality.
R. F. Istiqlal, K. Listyarini, J. Jakaria, C. Budiman, A. Gunawan   +4 more
doaj   +1 more source

Analysis of Productive Performance of Crop and Animal Production Systems: An Integrated Analytical Framework [PDF]

This article presents a two-stage analytical framework that integrates ecological crop (animal) growth and economic frontier production models to analyse the productive efficiency of crop (animal) production systems.
Viet-Ngu Hoang
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Animal production and feeding [PDF]

, 2009
Organic livestock farmers will try to accommodate the natural needs and behaviour of their animals as much as possible. They pay extra attention to animal health and welfare, but also set high standards for housing, outside access and feed.
Hommes, M., Sukkel, W.
core   +1 more source