Results 181 to 190 of about 6,693,109 (309)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Urine Stable Isotope Ratios Are Associated with Proportional Intakes of Animal Protein and Added Sugars in a 15-Day Controlled Feeding Study. [PDF]

J Nutr
O'Brien DM, Freedman LS, Rivera P, Sagi-Kiss V, Palma-Duran SA, Barrett B, Commins J, Tasevska N.   +7 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The price of animal protein [PDF]

Nature Geoscience, 2009
openaire   +1 more source

Long-term effects of plant vs. animal protein supplementation on body composition, muscle strength, physical performance, and cardiometabolic risk factors in adults:a systematic review and meta-analysis of randomized controlled trials. [PDF]

Front Nutr
Yimam MA, Roberts J, O'Callaghan A, Holwerda A, Cassidy Y, Luiking Y, Van Helvoort A, Muscaritoli M.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Locally-Sourced Animal Protein Hydrolysates in High-Plant-Protein Diets Can Promote European Seabass Growth and Nutrient Utilization, Reducing Reliance on Fishmeal. [PDF]

Aquac Nutr
Rodrigues-Dos-Santos L, Basto A, Monteiro M, António C, Rodrigues AM, Sá T, Velasco C, Martins R, Rosa A, Pintado M, Almeida A, Valente LMP.   +11 more
europepmc   +1 more source

Erratum: Plant to animal protein ratio in the diet: nutrient adequacy, long-term health and environmental pressure. [PDF]

Front Nutr, 2023
Frontiers Production Office.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Olive Pomace and Melon Bio-Byproducts from the Agribusiness: A Promising Combination for the Sustainable Production of Animal Protein from BSF Larvae. [PDF]

Insects
Ligeiro C, Souza CSE, Fantatto R, Murta D.   +3 more
europepmc   +1 more source