Advanced Science, EarlyView.Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang +12 more
wiley +1 more source
Why genetic validation is crucial for identifying larval stages of <i>Arctica islandica</i> (Venerida, Arcticidae). [PDF]
ZookeysChaibi CA, Kniesz K, Zettler ML.
europepmc +1 more source
A Scalable Double‐Sided Wet Etching Strategy for Large‐Area Mushroom‐Shaped Bionic Adhesives
Advanced Science, EarlyView.This work presents a scalable manufacturing strategy for high‐performance, large‐area, mushroom‐shaped bio‐inspired adhesives. Using a double‐sided wet etching process, the complex 3D metal molds are fabricated rapidly and controllably. The resulting adhesive structures exhibit strong, stable adhesion under various conditions, including atmosphere and ...
Keju Ji +8 more
wiley +1 more source
Impact of landscape installation design on emotional loneliness: interaction style as a moderating factor. [PDF]
Front PsycholGong M.
europepmc +1 more source
An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Advanced Science, EarlyView.Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source
Uniqueness and predictability in evolution and the history of mollusks. [PDF]
Proc Natl Acad Sci U S AVermeij GJ, Thomson TJ.
europepmc +1 more source
Spontaneous Cyclic Levitation of Glycerol‐Water Droplets at Low Pressures
Advanced Science, EarlyView.Under low pressure, a minute glycerol addition transforms the chaotic dynamics of freezing water droplets into cyclic levitation. Freeze‐concentration preserves liquid pathways that relax expansion‐induced stress, while freezing point depression weakens asymmetric vaporization recoil.
Chen Xu +10 more
wiley +1 more source
Trimerous magnoliid flowers with a unique set of floral and pollen traits from the Late Cretaceous of Southern Bohemia (Czech Republic). [PDF]
New PhytolWu X +7 more
europepmc +1 more source
Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications
Advanced Science, EarlyView.Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen +11 more
wiley +1 more source
Two New Species of the Genus <i>Philanthaxia</i> Deyrolle, 1864, from Hainan Province, China (Coleoptera, Buprestidae, Thomassetiini). [PDF]
InsectsNi T, Qi Z, Peng X, Song H, Wang R.
europepmc +1 more source