Results 61 to 70 of about 14,097 (254)
, 2016 Ethical vegetarians maintain that vegetarianism is morally required. The principal reasons offered in support of ethical vegetarianism are: (i) concern for the welfare and well-being of the animals being eaten, (ii) concern for the environment, (iii ...
AR Mangels +9 more
core +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Where Value Resides:Making Ecological Value Possible [PDF]
, 2015 Distinguishing between the source and the locus of value enables environmental philosophers to consider not only what is of value, but also to try to develop a conception of valuation that is itself ecological. Such a conception must address difficulties
Greaves, Thomas, Read, Rupert
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Human Relationships with Domestic and Other Animals: One Health, One Welfare, One Biology
Animals, 2019 Excessive human population growth, uncontrolled use of natural resources, including deforestation, mining, wasteful systems, biodiversity reduction by agriculture, and damaging climate change affect the existence of all animals, including humans.
Ariel M Tarazona +2 more
doaj +1 more source
Pain, Life, and God: Theodicy Informed by Biology and Evolutionary Medicine
Religions, 2023 Pain is a ubiquitous phenomenon. Since the beginnings of philosophical thought, the question of the nature and origin of pain has developed. However, it also raises the question of how an omnipotent and morally perfect God can allow so much pain and ...
Sasa Horvat
doaj +1 more source
The Great God Pan is Not Dead – A. N. Whitehead and the Psychedelic Mode of Perception [PDF]
, 2017 Through Alfred North Whitehead’s metaphysics, the Philosophy of Organism, it will be argued that psychedelic experience is a vertical, lateral and temporal integration of ...
Sjöstedt-H., Peter
core
Putting a number on the harm of death [PDF]
, 2019 Donors to global health programs and policymakers within national health systems have to make difficult decisions about how to allocate scarce health care resources. Principled ways to make these decisions all make some use of summary measures of health,
Millum, Joseph
core +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source