Results 121 to 130 of about 7,407,230 (297)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

MANURE BMP ADOPTION AMONG NORTH DAKOTA ANIMAL FEED OPERATIONS [PDF]

open access: yes
Regulations governing animal waste storage are primarily a state-level issue. Protecting water resources from animal waste contamination will depend upon how effective state-level animal waste regulations are in encouraging livestock producers to handle ...
Schuck, Eric C., Birchall, Scott
core  

Organização do trabalho em colônias de saúvas: relações com locais e objetos das atividades

open access: yesPsicologia USP
Este trabalho relata os resultados principais de um projeto de pesquisa sobre divisão de trabalho em colônias artificiais da saúva. Atividades desempenhadas dentro e fora da colônia foram analisadas em termos de sua distribuição entre classes de obreiras,
Ana Maria Almeida Carvalho
doaj  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Animal Experimentation Ethics Committee B

open access: yes, 2016
This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete.
University of Melbourne. Animal Experimentation Ethics Committee
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Animal Health News

open access: yes, 2017
This internet resource contains issues published throughout multiple yearsSmall Animal Facilities Seminar Cervid Tuberculosis And Brucellosis Canine Brucellosis Staff Spotlight Dr. Bill Brown Dr.
Kansas Animal Health
core  

Feeding and the Equilibrium Feeder Animal Price-Weight Schedule [PDF]

open access: yes
Feeder animal prices depend on fed animal prices, the biological growth technology, and feed costs. In addition, daily maintenance costs can be avoided through accelerated feeding.
Hennessy, David A.
core   +2 more sources

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