Results 131 to 140 of about 642,579 (262)
Leskov's Ledi Makbet Mtsenskogo uezda: composition and symbolic framework [PDF]
, 2007 This article examines the distinctive Leskovian composition of recurrent, linking and overlapping detail and motifs — and the density and open-ended character of the meanings they generate — in his classic story Ledi Makbet Mtsenskogo uezda (Lady Macbeth
Aizlewood, R.
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The Privatization of Sensation [PDF]
, 2000 It is the ambition of evolutionary psychology to explain how the basic features of human mental life came to be selected because of their contribution to biological survival.
Humphrey, Nicholas
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Buletin Udayana Mengabdi, 2014 Animal health service is one of key factors to be successful in animal breeding. This program include curativeaction for animal illness, sanitation program and vaccination as a preventive program.
I W AYAN SUARDANA
doaj
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Bulletin of the Center for Children's Books 47 (09) 1994 [PDF]
, 1994 published or submitted for ...
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Conscientização de adolescentes sobre a guarda responsável de animais
Revista Ciência em Extensão, 2013 A domesticação dos animais, ocorrida há muitos anos, intensificou a relação de dependência homem-animal. Esta proximidade resultou em um crescente número de animais de companhia e conseqüente aumento do número de animais errantes nos centros urbanos ...
Thaline Segatto +4 more
doaj
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source