Results 71 to 80 of about 641,866 (350)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Emphasizing Common Childhood Anxieties in Children’s Fantasy: An Analysis of the Illustrations in Matilda and Charlotte’s Web [PDF]
, 2017 In children’s literature, illustrations are just as important to story as a book’s text; illustrations contribute to the overall tone of the story and to the way readers interpret its ...
Erhart, Ellie
core +1 more source
Dancing horses and reflecting humans [PDF]
, 2014 In October 2012, German dancer and philosopher Aurelia Baumgartner presented her 90-minute production Tanzende Pferde: Spiegelungen im Raum/Dancing Horses: Reflections in Space.
Meyer-Dinkgräfe, Daniel
core +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Danish Journal of ArchaeologyThis article examines the role of Scandinavian animal styles in the early Viking Age. It first assesses several strands of relevant discourse in the research history. One line of argument suggests a link between early and late animal styles.
Mats Skare
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A Novel Approach to Artistic Textual Visualization via GAN
, 2017 While the visualization of statistical data tends to a mature technology, the visualization of textual data is still in its infancy, especially for the artistic text.
Ma, Muhan, Ma, Yichi
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Feeling, Not Freedom: Nietzsche Against Agency [PDF]
, 2016 Despite his rejection of the metaphysical conception of freedom of the will, Nietzsche frequently makes positive use of the language of freedom, autonomy, self-mastery, self-overcoming, and creativity when describing his normative project of enhancing ...
Miyasaki, Donovan
core