Results 81 to 90 of about 642,579 (262)

The qualitative assessment of responsiveness to environmental challenge in horses and ponies. [PDF]

, 2008
The responsiveness of 10 horses and 10 ponies to environmental challenge (represented by an open field test) was assessed using a qualitative approach based on free choice profiling methodology (FCP), which gives observers complete freedom to choose ...
BORDI, ALDO, BRAGHIERI A, DE ROSA, GIUSEPPE, GRASSO, FERNANDO, NAPOLITANO F, WEMELSFELDER F.   +5 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Burial of the Scythian Period with Bridle Set in the Animal Style from the Burial Adryg

Oriental Studies, 2018
Scythian and Syberian animal style is a specific peculiarity of archeological culture in the Scythian era. The distinctive manner for animal representation is widely used in cultures of the late Bronze and early Iron Age.
M. Ochir-Gorjaeva, E. Burataev
doaj  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Feeling, Not Freedom: Nietzsche Against Agency [PDF]

, 2016
Despite his rejection of the metaphysical conception of freedom of the will, Nietzsche frequently makes positive use of the language of freedom, autonomy, self-mastery, self-overcoming, and creativity when describing his normative project of enhancing ...
Miyasaki, Donovan
core  

The attachment system and physiology in adulthood: normative processes, individual differences, and implications for health. [PDF]

, 2014
Attachment theory provides a conceptual framework for understanding intersections between personality and close relationships in adulthood. Moreover, attachment has implications for stress-related physiology and physical health.
Ainsworth, Avitsur, Baumeister, Beedie, Biomarker Definitions Working Group, Bolger, Bowlby, Bowlby, Bowlby, Brennan, Brooks, Bullmore, Carmichael, Coan, Coan, Collins, Collins, Collins, Collins, Dallman, DeVries, DeWall, Diamond, Diamond, Diamond, Diamond, Dickerson, Eisenberger, Epel, Fraley, Fraley, Gailliot, Gouin, Hagger, Hasler, Hazan, Hazan, Hicks, Hofer, Holland, Holt-Lunstad, Kane, Kidd, Kiecolt-Glaser, Kiecolt-Glaser, Kiecolt-Glaser, Kirschbaum, Kurzban, Laurenceau, Lovallo, Master, Maunder, Maunder, McClure, McEwen, McWilliams, Mikulincer, Miller, Molden, Pasch, Peters, Pietromonaco, Polan, Powers, Quirin, Ridker, Roberts, Robles, Robles, Robles, Roisman, Salvy, Sanders, Sapolsky, Sbarra, Scharfe, Souza, Stumvoll, Taylor, Troxel, Troxel, Troxel, Troxel, Uchino, Vaishnavi, Vormbrock, Vrtička, Vrtička, Walburn   +88 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Emphasizing Common Childhood Anxieties in Children’s Fantasy: An Analysis of the Illustrations in Matilda and Charlotte’s Web [PDF]

, 2017
In children’s literature, illustrations are just as important to story as a book’s text; illustrations contribute to the overall tone of the story and to the way readers interpret its ...
Erhart, Ellie
core   +1 more source