Results 121 to 130 of about 4,797,624 (302)

Protocol for single-use Ambu aScope-based minimally invasive bronchoalveolar lavage collection in pigs

STAR Protocols
Summary: Here, we present a protocol for collecting bronchoalveolar lavage (BAL) samples from live pigs using a single-use Ambu aScope. We describe the steps for animal preparation, BAL collection, and sample handling, including downstream analysis, to ...
Piyush Baindara, Dinata Roy, Addison K. Byrne, Jonathan A. Green   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Animal Testing: Scientific Testing and Animal Welfare [PDF]

Animal testing can be dated back thousands of years to ancient Greece, when early scientists such as Aristotle performed experiments on live animals. Early physicians used animals to test surgical procedures before using them on humans.
Girón-Anderson, Ella
core  

Cytotoxicity assay as a potential alternative method for animal testing for batch release of Italian fish autogeneous vaccines. [PDF]

Open Vet J, 2023
Di Paolo A, Anzalone L, Pellegrini M, Severi G, Cagiola M.   +4 more
europepmc   +1 more source

Animal tests inescapable [PDF]

Nature, 2008
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Animal Health News

This internet resource contains issues published throughout multiple yearsHighly Pathogenic Avian Influenza(HPAI) in Livestock -- How can dairy producers help?
Kansas Animal Health
core  

Bioreactor analyses of tissue ingrowth, ongrowth and remodelling around implants: An alternative to live animal testing. [PDF]

Front Bioeng Biotechnol, 2023
Kohli N, Theodoridis K, Hall TAG, Sanz-Pena I, Gaboriau DCA, van Arkel RJ.   +5 more
europepmc   +1 more source

Ethics and artificiality

Inscriptions, 2018
This essay interrogates the place of ethics, which needs to be located  in philosophy alongside studies of being. Ethics is not an omniscient field of study: there is a room outside ethics, and yet there is ethics.
Wolfgang Schirmacher, Daniel Theisen
doaj  

Towards learning and memory risk assessment with human brain organoids: barriers and opportunities

Frontiers in Toxicology
Neurodevelopmental conditions, including autism spectrum disorder, intellectual disability, and learning disabilities, as well as neurodegenerative disorders, affect millions of people in the United States alone.
Ronit Mohapatra, Dowlette-Mary Alam El Din, Hanyu Zhao, Hanyu Zhao, Thomas Hartung, Thomas Hartung, Lena Smirnova   +6 more
doaj   +1 more source