Results 161 to 170 of about 809,866 (309)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

In ovo model with emu eggs as novel alternative to animal testing in preclinical imaging research. [PDF]

EJNMMI Res
Perkas O, Pomraenke M, Porwoll V, Kühnel C, Wiegand S, Herrmann KH, Winkens T, Freesmeyer M.   +7 more
europepmc   +1 more source

Curated Data In - Trustworthy In Silico Models Out: The Impact of Data Quality on the Reliability of Artificial Intelligence Models as Alternatives to Animal Testing. [PDF]

Altern Lab Anim, 2021
Alves VM, Auerbach SS, Kleinstreuer N, Rooney JP, Muratov EN, Rusyn I, Tropsha A, Schmitt C.   +7 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Bioprinting for drug screening: A path toward reducing animal testing or redefining preclinical research? [PDF]

Bioact Mater
Budharaju H, Singh RK, Kim HW.
europepmc   +1 more source

Structured approach to design of diagnostic test evaluation studies for chronic progressive infections in animals

, 2011
Søren Saxmose Nielsen, Nils Toft, Ian A. Gardner   +2 more
openalex   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Artificial intelligence-, organoid-, and organ-on-chip-powered models to improve pre-clinical animal testing of vaccines and immunotherapeutics: potential, progress, and challenges. [PDF]

Front Artif Intell
Elfatimi E, Lekbach Y, Prakash S, Karan S, Dorotta JC, Garcia A, Suoth BS, Maurya C, Omorogieva EY, Ng SXL, Liao EJ, Chow RA, BenMohamed L.   +12 more
europepmc   +1 more source

18. Estimation of Meat Content in the Carcasses of Young Pigs Based on Performance Testing of Live Animals and Carcass Evaluation [PDF]

, 2015
Magdalena Szyndler‐Nędza, R. Eckert, Tadeusz Blicharski   +2 more
openalex   +1 more source

Brucella antigen purification for the diagnosis of animal brucellosis with indirect ELISA test [PDF]

, 2020
V.G. Homenko, Y.V. Homenko, V. V. Ukhovskyі, T.O. Diacyenko   +3 more
openalex   +1 more source