Results 161 to 170 of about 4,797,624 (302)

Public perception of laboratory animal testing: Historical, philosophical, and ethical view. [PDF]

Addict Biol, 2021
Petetta F, Ciccocioppo R.
europepmc   +1 more source

Prevalence of Unregistered, Substandard, and Falsified Veterinary Antimicrobials in Ethiopia: A National Postmarket Quality Surveillance Study

Veterinary Medicine International
Belachew Tefera, Belachew Bacha, Nardos Tefera, Gudeta Uma, Tadese Setegn, Bizuayehu Belete, Diriba Daba, Dinsefa Jemal, Yilak Tefera, Hussen Bedu, Tamiru Tilki, Dagnachew Hailemichael, Solomon Kebede, Hamid Jemal, Tesfa Marew, Dawit Teshome, Teferi Gedif, Esayas Gelaye, Tenaw Andualem, Ayenew Ashenef   +19 more
doaj   +1 more source

Animal Testing [PDF]

, 2020
openaire   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

FDA roadmap to reducing animal testing: a regulatory and scientific paradigm shift in nonclinical safety assessment. [PDF]

Stem Cell Res Ther
Lei Y, Tuan RS, Li ZA.
europepmc   +1 more source

Novel computational models offer alternatives to animal testing for assessing eye irritation and corrosion potential of chemicals. [PDF]

Artif Intell Life Sci, 2021
Silva AC, Borba JVVB, Alves VM, Hall SUS, Furnham N, Kleinstreuer N, Muratov E, Tropsha A, Andrade CH.   +8 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A chemically optimized, GalNAc-conjugated siRNA targeting HSD17B13 demonstrates efficacy in a human 3D organoid model of MASH, showcasing an alternative to animal testing. [PDF]

PLoS One
Meng Q, Wang X, Zhang Y, Pushpakom S, Yang J, Feng H, Wang M.   +6 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

From animal testing to model-informed drug development: building on ICH M15 and EMA initiatives to make new approach methodologies (NAMs) deliver. [PDF]

Front Pharmacol
Dogné JM, Locquet M, Musuamba F, Beken S.   +3 more
europepmc   +1 more source