Results 191 to 200 of about 4,797,624 (302)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Maximizing Insights, Minimizing Animal Testing: A Framework for Validating Multiparametric Single-Cell Cytokine Analysis Panels. [PDF]

Eur J Immunol
Aleith J, Bergmann-Ewert W, Müller-Hilke B.   +2 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Taking the 3Rs to a higher level: replacement and reduction of animal testing in life sciences in space research. [PDF]

Biotechnol Adv
Vinken M, Grimm D, Baatout S, Baselet B, Beheshti A, Braun M, Carstens AC, Casaletto JA, Cools B, Costes SV, De Meulemeester P, Doruk B, Eyal S, Ferreira MJS, Miranda S, Hahn C, Helvacıoğlu Akyüz S, Herbert S, Krepkiy D, Lichterfeld Y, Liemersdorf C, Krüger M, Marchal S, Ritz J, Schmakeit T, Stenuit H, Tabury K, Trittel T, Wehland M, Zhang YS, Putt KS, Zhang ZY, Tagle DA.   +32 more
europepmc   +1 more source

Animal testing for vaccines. Implementing replacement, reduction and refinement: challenges and priorities. [PDF]

Biologicals, 2020
Akkermans A, Chapsal JM, Coccia EM, Depraetere H, Dierick JF, Duangkhae P, Goel S, Halder M, Hendriksen C, Levis R, Pinyosukhee K, Pullirsch D, Sanyal G, Shi L, Sitrin R, Smith D, Stickings P, Terao E, Uhlrich S, Viviani L, Webster J.   +20 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

A twin transition in regulatory toxicology: moving toward Chemicals 2.0 and phasing out animal testing. [PDF]

Toxicol Sci
Worth AP, Berggren E.
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Alternatives to animal testing to assess MASH drugs and hepatotoxicity. [PDF]

Hepatology
Brenner DA, Brenner DA.
europepmc   +1 more source

Animals in Biomedical Testing

Abstract This chapter examines the economic dimensions of the transition from traditional animal testing to New Approach Methodologies (NAMs) in safety sciences. Drawing on data from regulatory agencies, industry trends, and technological innovations, it articulates how ethical motivations have been joined—if not ...
openaire   +1 more source