Results 71 to 80 of about 1,698,103 (349)

Animal testing: TV or not TV? [PDF]

Nature, 2011
Two views on whether scientists who believe that animal experimentation is necessary should become public advocates, or work quietly behind the scenes.
Aziz, T, Stein, J, Yogeshwar, R
openaire   +3 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

A novel spine tester TO GO

JOR Spine
Background Often after large animal experiments in spinal research, the question arises—histology or biomechanics? While biomechanics are essential for informed decisions on the functionality of the therapy being studied, scientists often choose ...
Jan Ulrich Jansen, Laura Zengerle, Marcel Steiner, Vincenza Sciortino, Marianna Tryfonidou, Hans‐Joachim Wilke   +5 more
doaj   +1 more source

Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury

Frontiers in Drug Discovery
Predicting which drugs might have the potential to cause drug-induced liver injury (DILI) is highly complex and the current methods, 2D cell-based models and animal tests, are not sensitive enough to prevent some costly failures in clinical trials or to ...
K. Taylor, R. Ram, R. Ram, L. Ewart, C. Goldring, G. Russomanno, G. P. Aithal, T. Kostrzewski, C. Bauch, J. M. Wilkinson, J. M. Wilkinson, S. Modi, J. G. Kenna, J. G. Kenna, J. Bailey, J. Bailey   +15 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Peran People for the Ethical Treatment of Animals (Peta) Dalam Kasus Animal Testing Terhadap Hewan Luwak Di Indonesia Tahun 2012-2014 [PDF]

, 2015
More than 100 million animals every year suffer and die by fierce chemical test, medical, food, and cosmetic by giving poisonous, blinding and killing million animals every year for irresponsible companies.
Ambarrini, T. (Tantin), Harto, S. (Syafri)   +1 more
core  

Motor hyperactivity of the iron-deficient rat - an animal model of restless legs syndrome. [PDF]

, 2017
BackgroundAbnormal striatal dopamine transmission has been hypothesized to cause restless legs syndrome. Dopaminergic drugs are commonly used to treat restless legs syndrome. However, they cause adverse effects with long-term use.
Allen, Allen, Allen, Berger, Bhalsing, Chervin, Connor, Dean, Degirmenci, Deleva, Earley, Earley, Earley, Eisensehr, Freeman, Happe, Hening, Hsieh, Iannaccone, Kabakus, Kim, Lee, Michaud, Michaud, Moccia, Mohri, Montplaisir, Montplaisir, Nikolaus, Novak, Polydefkis, Sarova-Pinhas, Schattschneider, Trenkwalder, Tursi, Ylikoski, Zucconi   +36 more
core   +1 more source

Relevant Species Selection for Preclinical Safety Studies of Medicines: A Review

Безопасность и риск фармакотерапии
INTRODUCTION. The use of relevant species of laboratory animals in preclinical safety studies during the development of novel medicines provides valuable information for assessing the risks and benefits of such medicines for humans.
G. N. Engalycheva, R. D. Syubaev
doaj   +1 more source

Ethical and Legal Implications of Animal Use in Didactic Situations: The Conceptions of undergraduate Biology and Biomedicine students of a Federal Institution of Higher Education located in the State of Rio de Janeiro – Brazil [PDF]

Investigações em Ensino de Ciências, 2011
The use of animals in teaching situations is one of the methods of animal experimentation that has been institutionalized in the scientific context of the eighteenth century, when it was believed that animals had no soul or feel pain.
Izabel Christina Pitta P. de S. Melgaço, Rosane M. S. Meirelles, Helena Carla Castro   +2 more
doaj  

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source