Results 141 to 150 of about 2,912 (306)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

On Matthew Barney: Deadpan Conceptualism, Animality, and Sculpture

open access: yes, 2015
This dissertation explores and theorizes the work of American artist Matthew Barney through the concept of deadpan, and situates it in relation to themes of hybridity and animality in parallel histories of sculpture, performance art, and film.
Routh, Mitali Jones
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Disability and animality ::crip perspectives in critical animal studies /

open access: yes, 2020
"The fields of Critical Disability Studies and Critical Animal Studies are growing rapidly, but how do the implications of these endeavours intersect? Disability and Animality: Crip Perspectives in Critical Animal Studies explores some of the ways that ...
Taylor, Chloë,   +2 more
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Hobbes and Wolf-Man: Melancholy and Animality in Modern Sovereignty

open access: yes, 2010
Homo homini lupus, man is a wolf to man, remains one of the most well-known and often quoted dictums in the tradition of political theory. Political theorists take this phrase by Thomas Hobbes in the Epistle Dedicatory of De Cive to illustrate the ...
Rossello, Diego
core   +1 more source

Rendering the Unthinkable: (Un)knowable Animality, Compulsory Recovery, and Heterosexualized Trauma in The Hunger Games

open access: yes, 2014
Dystopian fiction is expected to reflect deeply on the interactions between identities, bodies, and state control. Suzanne Collins\u27s The Hunger Games Trilogy is no exception.
Polish, Jennifer
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

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