Results 241 to 250 of about 4,965,699 (338)

PGC-1 alpha overexpression in the skeletal muscle results in a metabolically active microbiome which is independent of redox signaling. [PDF]

Sci Rep
Koltai E, Mozaffaritabar S, Zhou L, Kolonics A, Koike A, Tanisawa K, Park J, Torma F, Radak Z.   +8 more
europepmc   +1 more source

Stereotyped Subclones Revealed by High‐Density Single‐Cell Lineage Tracing Support Robust Development

Advanced Science, EarlyView.
Based on a well‐established in vitro directed differentiation model and an integrated analysis of high‐density cell lineage trees (CLTs) and single‐cell transcriptomes, it is demonstrated that many subclones are formed by sub‐CLTs resembling each other in terms of both cell type compositions and topological structures.
Xiaoyu Zhang, Zizhang Li, Jingyu Chen, Wenjing Yang, Xingxing He, Peng Wu, Feng Chen, Ziwei Zhou, Chenze Ren, Yuyan Shan, Xiewen Wen, Vassily A. Lyubetsky, Leonid Yu. Rusin, Xiaoshu Chen, Jian‐Rong Yang   +14 more
wiley   +1 more source

Long-term impacts of captivity on skull morphology and endocranial volume in a marsupial carnivore. [PDF]

R Soc Open Sci
Scicluna EL, Parrott ML, Siciliano-Martina L, Michaud M, Robert K, Green PT.   +5 more
europepmc   +1 more source

Oysters and Vibrios as a Model for Disease Dynamics in Wild Animals.

Trends in Microbiology, 2016
F. Roux, F. Roux, K. M. Wegner, M. Polz
semanticscholar   +1 more source

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

Ice-olating a health scoring system for wild polar bears. [PDF]

Conserv Physiol
Muise KA.
europepmc   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Reintroduction training is instrumental in restoring the oral microbiota of giant pandas from "captivity" to "wildness". [PDF]

BMC Microbiol
Ma R, Yu X, Huang C, Xue F, Hou R, Wu W, Feng F, Bi W, Zhang L, Liu J, Li Z, Gu J, Zhou Y, Lan G, Chen C, Yao Y, Lan J, Luo L, Li P, He H, Zhang M, Yang X, Yang H, Gu H, Gu X, Chen L, Qi D.   +26 more
europepmc   +1 more source

RONIN/HCF1‐TFEB Axis Protects Against D‐Galactose‐Induced Cochlear Hair Cell Senescence Through Autophagy Activation

Advanced Science, EarlyView.
D‐galactose (D‐gal) induced inner ear hair cell senescence by inhibiting TFEB transcription. RONIN/HCF1 promotes TFEB transcription to prevent cochlear HCs from D‐gal‐induced senescence through autophagy activation. Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy.
Yongjie Wei, Yuhua Zhang, Wei Cao, Nan Cheng, Yun Xiao, Yongjun Zhu, Yan Xu, Lei Zhang, Lingna Guo, Jun Song, Su‐hua Sha, Buwei Shao, Fang Ma, Jingwen Yang, Zheng Ying, Zuhong He, Renjie Chai, Qiaojun Fang, Jianming Yang   +18 more
wiley   +1 more source

Effects of Flight Restraint and Housing Conditions on Feather Corticosterone in White Storks Under Human Care. [PDF]

Animals (Basel)
Liermann F, Baumgartner K, Simon R, Will H, von Fersen L, Merle R, Thöne-Reineke C.   +6 more
europepmc   +1 more source