Results 251 to 260 of about 4,965,699 (338)

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Epidemiological Surveillance of Intestinal Parasites and Serological Analysis of <i>Toxoplasma gondii</i> in Captive Felids From Thailand Zoos. [PDF]

Vet Med Int
Hongsrichan N, Donthaisong P, Chaisongkram C, Eamudomkarn C, Pitaksakulrat O, Ponsrila K, Mangkit B, Chalermwong P, Jarudecha T, Surapinit A, Boonmars T, Rucksaken R.   +11 more
europepmc   +1 more source

Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4‐Mediated Ferritinophagy Associated with Cisplatin‐Induced Hearing Loss

Advanced Science, EarlyView.
Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen, Cheng Cheng, Ao Li, Dengbin Ma, Siyu Li, Handong Wang, Song Gao, Dingding Liu, Panpan Song, Chenjie Yu, Xiaoyun Qian, Guoqiang Wan, Xia Gao   +12 more
wiley   +1 more source

Co-designing zoonotic diseases prevention practices when people depend on wild meat. [PDF]

One Health
Efoua Tomo N, Pouliquen A, Boupana Mapeyi GA, Makouloutou-Nzassi P, N'dilimabaka N, Ngoubangoye B, Cornelis D, Lebel S, Peyre M, Olive MM, Vanthomme H, Maganga GD, Delabouglise A.   +12 more
europepmc   +1 more source

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

Advanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi, Zejun Gao, Yang Qiu, Renfeng Wang, Keyong Tian, Bo Yue, Xinyu Zhang, Peng Zhang, Ziqi Wu, Qingwen Zhu, Zhenzhen Liu, Zhuoyao Ma, Xueying Zhou, Yu Han, Jun Chen, Jianhua Qiu, DingJun Zha   +16 more
wiley   +1 more source

Mitochondrial Phylogeography of Wild Boars, <i>Sus scrofa</i>, from Asia Minor: Endemic Lineages, Natural Immigration, Historical Anthropogenic Translocations, and Possible Introgression of Domestic Pigs. [PDF]

Animals (Basel)
Demirbaş Y, Soysal H, Koca AÖ, Stefanović M, Suchentrunk F.   +4 more
europepmc   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

The Activity Rhythm and Home Range Characteristics of Released Chinese Pangolins (<i>Manis pentadactyla</i>). [PDF]

Animals (Basel)
Huang H, Shen Z, Zhang X, Cheng H, Xie C, Zheng R.   +5 more
europepmc   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Human Infections by Novel Zoonotic Species Corynebacterium silvaticum, Germany. [PDF]

Emerg Infect Dis
Berger A, Dangel A, Melnikov VG, Bengs K, Rupp T, Mappes HJ, Schneider C, Sing A.   +7 more
europepmc   +1 more source