Results 271 to 280 of about 4,965,699 (338)

METTL14‐Mediated M6A Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex

Advanced Science, EarlyView.
METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang, Zhaoxin Gao, Ruinan Zhao, Pan Zhou, Jingxi Chen, Hui Zhang, Yawen Wang, Wenjie Zhu, Peng Gao   +8 more
wiley   +1 more source

PEZO-1 is not required for AMsh glial responses to mechanical stimulation and does not play a major role in nose touch avoidance in <i>C. elegans</i>. [PDF]

MicroPubl Biol
Fernandez-Abascal J, Hall JD, Bianchi L.
europepmc   +1 more source

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Awareness campaigns and strengthened prevention as alternatives to banning: Preventing zoonotic diseases from wildlife in the Democratic Republic of Congo. [PDF]

PLoS One
Yambayamba MK, Astbury CC, Carabin H, Gallo-Cajiao E, Lee KM, Mashinda DK, Masumu JM, Ruegg SR, Penney TL, Mapatano MA.   +9 more
europepmc   +1 more source

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

Neurons and molecules involved in noxious light sensation in Caenorhabditis elegans. [PDF]

G3 (Bethesda)
Dunkel E, Aoki I, Bergs A, Gottschalk A.
europepmc   +1 more source

Self‐Maintainable Electronic Materials with Skin‐Like Characteristics Enabled by Graphene‐PEDOT:PSS Fillers

Advanced Science, EarlyView.
Graphene‐PEDOT:PSS fillers revolutionize soft electronics by transforming jelly‐like materials into skin‐like systems with self‐healing, heat‐responsiveness, and multiplex sensing capabilities. This novel material exhibits exceptional printability, flexibility, and adhesiveness, enabling seamless integration into bioelectronics and tissue‐cyborganic ...
Morteza Alehosseini, Firoz Babu Kadumudi, Sinziana Revesz, Parham Karimi Reikandeh, Jonas Rosager Henriksen, Tiberiu‐Gabriel Zsurzsan, Jon Spangenberg, Alireza Dolatshahi‐Pirouz   +7 more
wiley   +1 more source

Evidence of Crimean-Congo hemorrhagic fever virus in livestock and wildlife in Northeastern Portugal. [PDF]

Sci Rep
Dos Santos FA, Duarte MD, Caçote A, Lourenço A, Maroco D, Varela AR, Bonifácio L, Pimpão M, Henriques M, Duarte A, Barros SC.   +10 more
europepmc   +1 more source

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

Comprehensive regional study of ESBL <i>Escherichia coli</i>: genomic insights into antimicrobial resistance and inter-source dissemination of ESBL genes. [PDF]

Front Microbiol
Di Marcantonio L, Chiatamone Ranieri S, Toro M, Marchegiano A, Cito F, Sulli N, Del Matto I, Di Lollo V, Alessiani A, Foschi G, Platone I, Paoletti M, D'Alterio N, Garofolo G, Janowicz A.   +14 more
europepmc   +1 more source