Results 151 to 160 of about 317,430 (333)

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

Sulfonated reduced graphene oxide modification layers to improve monovalent anions selectivity and controllable resistance of anion exchange membrane

, 2017
Graphene oxide with lamellar structure has attracted research interest in various fields. In this study, sulfonated reduced graphene oxide (S-rGO) nanosheets with negatively charged sulfonic acid groups were synthesized via a facile distillation ...
Congjie Gao, Jiangnan Shen, Shen, Jiangnan, Van der Bruggen, B., Kaini Tang, Lixin Xue, Xue, Lixin, Tang, Kaini, Gao, Congjie, Yan Zhao, Ruan, Huimin, Huimin Ruan, Zhao, Yan, B. Van der Bruggen   +13 more
core   +1 more source

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Operando Electrochemical Formation of Integrated Ni‐Fe Oxyhydroxide Anode for Durable Anion Exchange Membrane Water Electrolyzer

Advanced Science, EarlyView.
The interfacial stability and activity of Ni‐Fe‐based AEMWE anodes can be directly enhanced by operando voltage‐cycling in a FeOOH‐containing electrolyte. This process simultaneously induces Ni oxidation and Fe incorporation, forming an integrated, porous (Fe, Ni)OOH layer with high conductivity and durability.
Euntaek Oh, Jonghyun Hyun, Hojin Lee, Changsoo Lee, Jang Yong Lee, Dong Wook Lee, Kyunghwa Seok, Jeesoo Park, Susung Kim, Gisu Doo, Hee‐Tak Kim   +10 more
wiley   +1 more source

Structural and Compositional Effects on the Scintillation Properties of Fast Emitting Metal‐Organic Frameworks

Advanced Science, EarlyView.
The crystalline structure, the atomic numbers of the constituent elementsand the size of MOF crystals each influence their photoluminescence and scintillation properties in distinct ways. Together, these factors provide valuable guidelines for designing systems with optimized performance and tunable timing characteristics, arising from the synergistic ...
Francesca Cova, Jacopo Perego, Biplab Joarder, Nobuhiro Yanai, Anna Vedda, Silvia Bracco, Angiolina Comotti, Angelo Monguzzi, Irene Villa   +8 more
wiley   +1 more source

Ion-Exchange Membrane Separation Processes

, 2004
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Strathmann, H., Strathmann H., Strathmann, Strathman   +3 more
core  

Preparation and characterization of imidazolium-functionalized poly (ether sulfone) as anion exchange membrane and ionomer for fuel cell application

, 2013
Imidazolium-functionalized anion exchange membranes (AEMs) for anion exchange membrane fuel cells (AEMFCs) were synthesized by functionalization of chloromethylated poly (ether sulfone) (PES) with 1-alkylimidazole.
Zhang, Geng, 邵志刚, Lu, Wangting, Shao, Zhi-Gang, Zhao, Yun, Li, Jin, Yi, Baolian   +6 more
core   +1 more source

Hydrophobicity Modulated Interfacial Water Distribution for Enhanced Kinetics of HER

Advanced Science, EarlyView.
In electrocatalysis, hydrophilic structures improve interfacial water management by forming a continuous, compact water film that facilitates proton/hydrogen transport, thereby lowering the effective adsorption free energy of H*. By contrast, hydrophobic structures enable rapid gas transport and promote the capture and local enrichment of gaseous ...
Yucheng Dong, Xinfa Wei, Xiangdong Xue, Hanxiao Wang, Qing Dong, Jian Liu   +5 more
wiley   +1 more source