Results 201 to 210 of about 80,553 (266)

Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin‐Active Carbohydrate Sulfatases

Angewandte Chemie, EarlyView.
We report plate‐based coupled assays to rapidly and quantitatively determine the activity and selectivity of mucin‐active carbohydrate sulfatases. This fluorogenic assay further enables inhibitor identification and allows determination of (sub‐)cellular location. ABSTRACT Sulfated glycans play a central role in human health and influence cell signaling,
Charles W. E. Tomlinson, Madouc D. Bergers, David N. Bolam, Ana S. Luis, Alan Cartmell, Zachary Armstrong   +5 more
wiley   +1 more source

Pacific Blue Derivatives of Paclitaxel as Fluorescent Probes of OATP1B-Type Transporters. [PDF]

Clin Transl Sci
Nepal MR, Xu Y, Jin Y, Hu P, Hu X, Rane DS, Andres AE, Ahmed EA, Steiger B, Sparreboom A, Peterson BR, Hu S.   +11 more
europepmc   +1 more source

Selective Nitrate Transmembrane Transport Through Adaptive Weak C─H Bonding Cyanostilbene Water Channels

Angewandte Chemie, EarlyView.
Here we demonstrate that weak HB CH donor cyanostilbenes promote water/ion transport through their ability to form less‐ordered transient water channels within the lipid bilayer with increased water permeability and NO3−/ Cl− selectivity. ABSTRACT Transmembrane water transport strongly depends on how dynamic, translocating water clusters are stabilized
Ioan Stroia, Dan‐Dan Su, Yuhao Li, Niculina Hadade, Ion Grosu, Arie van der Lee, Mihail Barboiu   +6 more
wiley   +1 more source

Krisanaklan Reduces Intestinal Anion and Fluid Secretion Through Inhibition of Na⁺/K⁺-ATPase and K⁺ Channel Activity. [PDF]

Ann N Y Acad Sci
Groeneweg TA, Baigal E, Leung A, Kremers GJ, Bijvelds MJC.   +4 more
europepmc   +1 more source

Specific Ion Effects of Chaotropic and Superchaotropic Anions Probed by Raman Hydration‐Shell Spectroscopy

Angewandte Chemie, EarlyView.
The vibrational frequencies of “dangling” water O─H bonds can be determined by Raman hydration‐ shell spectroscopy and used to differentiate chaotropes from kosmotropes and hydrophobes. Dangling O─H bonds are also detected around superchaotropic anions of the borate cluster type (B12X122−; X = H, F, Cl, Br, and I) but their frequencies do not directly ...
Werner M. Nau, Denilson Mendes de Oliveira, Andres S. Urbina, Harald Knorke, Jonas Warneke, Andrea Barba‐Bon, Dor Ben‐Amotz   +6 more
wiley   +1 more source

NDUFA4 Deletion Upregulates VDAC1 to Promote Mitochondrial Damage, Endoplasmic Reticulum Expansion, and Neuronal Apoptosis. [PDF]

Hum Mutat
Li L, Fu F, Li R, Zhou H, Huang R, Lu J, Guo F, Chen H, Lei T, Han J, Zhen L, Pan M, Li D, Liao C.   +13 more
europepmc   +1 more source

Perilipin‐2‐Anchored Lipid Droplet‐Targeting Phototheranostics

Angewandte Chemie, EarlyView.
This study reports two NIR theranostic dyes, C‐BDP‐OH and C‐BDP‐OMe. C‐BDP‐OMe targets lipid droplets via a dual‐anchoring mechanism with PLIN2, enabling wash‐free tumor imaging. With 62.6% photothermal conversion efficiency, it achieves tumor ablation by downregulating PLIN2, disrupting LD‐mitochondria crosstalk, and triggering apoptosis and ...
Lipeng Zhang, Jiyoung Yoo, Juan Bai, Sunghyun Kim, Yesim Bakan, Yongbin Zhang, Fangjun Huo, Jingying Zhou, Caixia Yin, Jong Seung Kim   +9 more
wiley   +1 more source

Drug-Drug Interactions in Recently Approved Antibacterials: A Mini Review. [PDF]

Eur J Drug Metab Pharmacokinet
Baccari I, Bergmann F, Zeitlinger M.
europepmc   +1 more source

Redirecting Excited‐State Proton Transfer Through Supramolecular Polymerization in Nanoconfinement

Angewandte Chemie, EarlyView.
Supramolecular confinement redirects the excited‐state proton transfer pathway of an amphoteric emitter. In water, the molecule undergoes ESPD, whereas co‐assembly with γ‐cyclodextrin forms nanotubes that template slip‐stacked emitter pairs and enable ESIMPT. Structural and photophysical characterization of the assemblies shows that the preorganization
Luis C. Pantaleone, Robert Hutchings, Bente Reus, Jacopo Martinelli, Alessia Lasorsa, Patrick C. A. van der Wel, Marc C. A. Stuart, Wesley R. Browne, Tibor Kudernac   +8 more
wiley   +1 more source

Nucleotide Variant in the <i>SLC26A9</i> Gene in Two Siblings with Cystic Fibrosis. [PDF]

J Clin Med
Krusiński A, Grenda A, Obara A, Węgrzyn-Szkutnik I, Zygmunt W, Winiarska H, Kuźnar-Kamińska B, Gajek Ł, Siwiec J, Krawczyk P, Milanowski J.   +10 more
europepmc   +1 more source