Results 81 to 90 of about 443,594 (243)

Ambulatory Assessment of Ankle and Foot Dynamics [PDF]

, 2007
Ground reaction force (GRF) measurement is important in the analysis of human body movements. The main drawback of the existing measurement systems is the restriction to a laboratory environment. This paper proposes an ambulatory system for assessing the
Koopman, H.F.J.M., Schepers, H. Martin, Veltink, Peter H.   +2 more
core   +2 more sources

A Soft Wearable Robot with an Adjustable Twisted String Actuator and a Two‐Stage Transmission Mechanism for Manual Handling Tasks

Advanced Intelligent Systems, EarlyView.
This article proposes a soft wearable robot (WeaRo) to assist workers while executing manual handling tasks. With its innovative design, the WeaRo effectively assists multiple body parts during manual handling tasks while using a single motor. Furthermore, the components of the WeaRo are assembled onto a fabric‐based suit, ensuring high performance and
Dongun Lee, Sinyoung Lee, Donghyun Lee, Dongjun Shin   +3 more
wiley   +1 more source

Liquid Metal Sloshing for High‐Load Active Self‐Healing System: An Application to Tendon‐Driven Legged Robot

Advanced Intelligent Systems, EarlyView.
Liquid metal “sloshing” by the robot's own actuator is proposed to improve the self‐healing performance. The proposed method drastically enhances the healed strength by decomposing the surface oxides and the impurities. The method contributes to the world's first demonstration of active self‐healing behavior performed by a life‐sized legged robot. Self‐
Shinsuke Nakashima, Kento Kawaharazuka, Yuya Nagamatsu, Koki Shinjo, Akihiro Miki, Yuki Asano, Yohei Kakiuchi, Kei Okada, Masayuki Inaba   +8 more
wiley   +1 more source

Tall Stature and Scoliosis Associated With a Novel Homozygous Loss‐of‐Function Missense Variant in NPR3

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT NPR3‐related tall stature is characterized by tall stature, elongated big toes, and additional epiphyses in hand and foot bones. The condition is caused by biallelic loss‐of‐function variants affecting natriuretic peptide receptor 3 (NPR3). Five individuals from four different families have been reported.
Pierre Moffatt, Chantal Janelle, Valancy Miranda, Ghalib Bardai, Frank Rauch   +4 more
wiley   +1 more source

Case Report: Hypomyelinating Leukodystrophy Type 20 (HLD20) With Novel CNP Gene Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT This case report describes a child with hypomyelinating leukodystrophy type 20 (HLD20), a rare neurodegenerative disorder characterized by impaired myelin formation. The patient presented with multiple neurodevelopmental abnormalities, including delayed motor milestones, seizures, and abnormal facial features.
Malak Alghamdi, Ghaida Alghamdi, Khalid Hundallah, Dima Jamjoom, Naif Almontashiri, Essa Alharbi, Muhammad Umair, Majid Alfadhel   +7 more
wiley   +1 more source

A mouse coccygeal intervertebral disc degeneration model with tail‐looping constructed using a suturing method

Animal Models and Experimental Medicine, EarlyView.
A novel, simple coccygeal intervertebral disc degeneration model, using a suturing method for tail‐looping, without the need for external fixation and complex surgery. The model has high reproducibility and stability and overcomes the disadvantages of the existing animal models of disc degeneration.
Wei Xie, Zemao Huang, Ziyang Huang, Deqing Luo, Zhangxin Chen, Li Xie, Lingqi Zhu, Hui Liu, Kejian Lian, Paolo Alberton, Denitsa Docheva, Dasheng Lin   +11 more
wiley   +1 more source

Detecting New Lesions Using a Large Language Model: Applications in Real‐World Multiple Sclerosis Datasets

Annals of Neurology, EarlyView.
Objective Neuroimaging is routinely utilized to identify new inflammatory activity in multiple sclerosis (MS). A large language model to classify narrative magnetic resonance imaging reports in the electronic health record (EHR) as discrete data could provide significant benefits for MS research. The objectives of the current study were to develop such
Shane Poole, Nikki Sisodia, Kanishka Koshal, Kyra Henderson, Jaeleene Wijangco, Danelvis Paredes, Chelsea Chen, William Rowles, Amit Akula, Jens Wuerfel, Vishakha Sharma, UCSF Multiple Sclerosis and Neuroinflammation Center clinicians, Andreas M. Rauschecker, Roland G. Henry, Riley Bove   +14 more
wiley   +1 more source

Gout and NLRP3 inflammasome biology

Arthritis &Rheumatology, Accepted Article.
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilisation, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal‐induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley   +1 more source

Efficacy and safety of dotinurad versus febuxostat for the treatment of gout: a randomised, multicentre, double‐blind, phase 3 trial in China

Arthritis &Rheumatology, Accepted Article.
Objectives Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicentre, randomised, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad
Jia Sun, Yu Wang, Yongjing Cheng, Dongmei Guo, Jiankang Hu, Dongzhou Liu, Zhengnan Gao, Changgui Li, Yibing Lu, Xiaodan Kong, Yu Liu, Zhenyu Jiang, Bin Yi, Hongfeng Zhang, Baijie Xu, Shihao Yu, Rieko Kokan, Kohei Ishikawa, Mikiko Kawakatsu, Zhuoli Zhang   +19 more
wiley   +1 more source

Genetic causal association between heart failure, frailty and poisoning by narcotics and psychodysleptics: A two‐sample Mendelian randomization

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Observational studies have suggested associations between heart failure (HF), frailty and poisoning by narcotics and psychodysleptics (PNP). However, establishing causal relationships has been challenging. This study used a two‐sample Mendelian randomization (MR) approach to investigate the genetically proxied causality between HF ...
Bing Wang, Hong Yu, Meng Cai, Xianqiao Xie   +3 more
wiley   +1 more source