Results 81 to 90 of about 300,320 (248)

Common carotid intima media thickness and ankle-brachial pressure index correlate with local but not global atheroma burden:a cross sectional study using whole body magnetic resonance angiography [PDF]

, 2014
Common carotid intima media thickness (CIMT) and ankle brachial pressure index (ABPI) are used as surrogate marker of atherosclerosis, and have been shown to correlate with arterial stiffness, however their correlation with global atherosclerotic burden ...
Belch, Jill J. F.; id_orcid, Belch, Jill J F, Faisel Khan, Stephen J Gandy, Gardner, Michael, Weir-McCall, Jonathan R., Rauchhaus, Petra, Adamson, Carly L., Gandy, Stephen J., Gandy Stephen J., Morris, Andrew D., Rauchhaus Petra, Houston, J. Graeme, Allan D Struthers, Lambert, Matthew A., Matthew A Lambert, J Graeme Houston, Ramkumar Prasad Guntur, Struthers Allan D., Lambert Matthew A., Gardner Michael, Adamson Carly L., Jill J F Belch, Michael Gardner, Khan, Faisel; id_orcid, Petra Rauchhaus, Weir-McCall Jonathan R., Jonathan R Weir-McCall, Khan Faisel, Ramkumar, Prasad Guntur, Khan, Faisel, Belch Jill J. F., Morris Andrew D., Carly L Adamson, Struthers, Allan D., Houston J. Graeme, Andrew D Morris, Prasad Guntur Ramkumar   +37 more
core   +2 more sources

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Clinical outcome and concomitant injuries in operatively treated fractures of the lateral process of the talus

BMC Musculoskeletal Disorders, 2019
Background The aim of this study was to review the patient rated outcome (PROM) of surgically treated fractures to the lateral process of the talus (LPTF) and identify factors influencing the outcome. Methods Retrospective study with a current follow-up.
Hubert Hörterer, Sebastian Felix Baumbach, Stefan Lemperle, Sebastian Altenberger, Oliver Gottschalk, Alexander Tobias Mehlhorn, Anke Röser, Markus Walther   +7 more
doaj   +1 more source

Approximate Analytical Model for the Squeeze-Film Lubrication of the Human Ankle Joint with Synovial Fluid Filtrated by Articular Cartilage [PDF]

, 2010
The aim of this article is to propose an analytical approximate squeeze-film lubrication model of the human ankle joint for a quick assessment of the synovial pressure field and the load carrying due to the squeeze motion.
Emilio Gòmez, Roberto D’Amato, D'Amato, Roberto, Alessandro Ruggiero, Ruggiero, Alessandro, Gomez Garcia, Emilio   +5 more
core   +1 more source

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

Advanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee, Jihyang Park, Xinyi Wang, Yueqi Deng, Jiashu Ren, Tao Zhou   +5 more
wiley   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Contact area, pressure distribution and mechanical stability in external arthrodesis of the ankle joint [PDF]

, 2009
The ankle joint is often affected by arthritis, giving a joint that is painful, stiff, and restricts movement. This can result in a huge loss of mobility for the sufferer.
Connor, Chris, Nabhani, Farhad, Hodgson, Steve, Hodgson, Simon, Connor, C. J.   +4 more
core  

Total ankle replacement for rheumatoid arthritis of the ankle.

, 2012
Rheumatoid arthritis is an autoimmune disease that may affect multiple joints, both small and large, and leads to numerous complications. The standard surgical treatment for a rheumatoid arthritic ankle has been an arthrodesis. The ideal candidate for an
Assal, M., Xavier, C., Sean, N.Y.
core   +1 more source

A Multimodal Intelligent System for Human Digital Twin Simulation with Continuous Kinematic Data Tracking, Biometric Prognosis, and Cognitive State Feedback in Industrial Environments

Advanced Intelligent Discovery, EarlyView.
This article implements a unified human digital twin framework that integrates cutting edge actuation, sensing, simulation, and bidirectional feedback capability. The approach includes integrating multimodal sensing, AI, and biomechanical simulation into one compact system.
Tajbeed Ahmed Chowdhury, Sebastian Gratz‐Kelly, Eric Wagner, Paul Motzki, Martina Lehser   +4 more
wiley   +1 more source