Results 231 to 240 of about 58,521 (295)

“Feminist Suffering” and “Aftermath Solidarity”: Repairing Female Solidarity in the Wake of a Friendship's Fall

Gender, Work &Organization, EarlyView.
ABSTRACT In my experience, the end of a female friendship came to symbolically represent the erosion of female solidarity as (I thought) I knew it. In this paper, I first present an evocative autoethnographic narrative that foregrounds the emotional toll of losing solidarity with a close childhood friend.
Daniela Aliberti
wiley   +1 more source

Final Analysis of the Phase 1/2 Trial of Valoctocogene Roxaparvovec for Severe Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Valoctocogene roxaparvovec is an adeno‐associated virus vector serotype 5 (AAV5)‐mediated gene therapy for severe haemophilia A (HA). Aim Report the final safety and efficacy results of the phase 1/2 trial of valoctocogene roxaparvovec. Methods An open‐label phase 1/2 trial (NCT02576795) enrolled adult males with severe HA (factor
Priyanka Raheja, Savita Rangarajan, Will Lester, Bella Madan, Glenn F. Pierce, Emily Symington, Carolyn Millar, Dane Osmond, Mingjin Li, Konstantia‐Maria Chavele   +9 more
wiley   +1 more source

Gait Pattern at Different Speeds in Persons With Haemophilia

Haemophilia, EarlyView.
ABSTRACT Introduction Persons with haemophilia (PwH) have a risk of bleeding in joints, especially in elbow, knee and ankle. In the long term, this leads to haemophilic arthropathy (HA), which results in joint deformities. Aim This study aims to examine how walking speed and HA affect (1) foot pressure distribution, (2) average vertical peak pressure ...
Marius Brühl, Pia Möllers, Jamil Hmida, Fabian Tomschi, Georg Goldmann, Frank A. Schildberg, Johannes Oldenburg, Andreas C. Strauss, Thomas Hilberg   +8 more
wiley   +1 more source

Real‐World Unmet Treatment Needs for Patients With Haemophilia: Results From the Global Adelphi Disease Specific Programme Database

Haemophilia, EarlyView.
ABSTRACT Introduction Prophylactic factor replacement and non‐factor therapy has improved bleed prevention and clinical outcomes for people with haemophilia (PwH). The remaining burdens faced by PwH in real‐world settings, despite availability of newer therapies, are not well documented.
Víctor Jiménez Yuste, Cléa Percier, Shwetha Prashanth, Nathan Ball, Ella Morton, Giancarlo Castaman   +5 more
wiley   +1 more source

An Ex Vivo Pharmacodynamic Study of KN057, a Tissue Factor Pathway Inhibitor Neutralizing Antibody, in Plasma Samples From Patients With Haemophilia or VWD3

Haemophilia, EarlyView.
ABSTRACT Introduction Tissue factor pathway inhibitor (TFPI), a key regulator of tissue factor‐initiated coagulation through FXa‐dependent inhibition of the tissue factor‐FVIIa complex, has emerged as a promising target for restoring thrombin generation.
Mankai Ju, Feng Xue, Wei Sun, Fang Li, Ting Xu, Renchi Yang   +5 more
wiley   +1 more source

Investigator‐Led Research to Improve the Diagnostic Assessment of Platelet Function Disorders: Reflections on the Challenges and Rewards

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Investigator‐led research and quality improvement initiatives have led to important improvements in the diagnostic assessment of platelet function disorders (PFD). Methods Personal reflections were used to summarize our contributions to knowledge on PFD diagnostic assessment, pathogenesis, and bleeding risks.
Catherine P. M. Hayward
wiley   +1 more source

AI‐enhanced decision support for fall patients: streamlining inpatient flow in the emergency department

International Transactions in Operational Research, EarlyView.
Abstract Emergency department (ED) overcrowding and inefficient patient flow are significant operational challenges, often amplified by the volume of patients sustaining fall‐related injuries. This study predicts hospital admission for these encounters by leveraging unstructured clinical text: triage chief complaints (reasons for seeking care) and ...
Dinesh R. Pai, Usha Ananthakumar, Shruti Sureshan   +2 more
wiley   +1 more source

Body mass index and peripheral neuropathy across the glucose tolerance spectrum in Japanese adults

Journal of Diabetes Investigation, EarlyView.
Graphical illustration of participant classification by metabolic status (normoglycemic, IGT, type 2 diabetes mellitus) and BMI with key neurological and metabolic assessments. In Japanese adults, obesity at the Japanese BMI threshold (≥25 kg/m2) is associated with adverse metabolic profiles across all glycemic states but exacerbates peripheral ...
Fukashi Ishibashi, Aiko Kosaka, Harumi Uetake, Darren C. Greenwood, Laura Güdemann, Hassan Fadavi, Mitra Tavakoli   +6 more
wiley   +1 more source

MRI‐based, 3D analysis of Achilles tendon longitudinal strain under passive loading reveals limitations in conventional 2D measurement

Journal of Anatomy, EarlyView.
Graphical overview of 2D and 3D length measurements of the free Achilles tendon. The figure also illustrates how the typical distal morphology of the soleus muscle affects 2D measurement. Abstract Quantifying strain in the free Achilles tendon (ATF) is essential for understanding its mechanical function, yet existing in vivo studies report inconsistent
Dongyu Deng, Hiroto Shiotani, Yasuo Kawakami   +2 more
wiley   +1 more source

Microanatomical features of bovids long bones: What are the effects of mass and habitat?

Journal of Anatomy, EarlyView.
This study provides the first qualitative and quantitative exploration of inter‐bones and interspecific variations in the microanatomy of long bones in bovids in response to significant changes in body mass and habitat. Abstract Bovids are a valuable group for studying limb long bone adaptations due to differences in size and the environment that the ...
Morgan Proust, Cyril Etienne, Alexandra Houssaye   +2 more
wiley   +1 more source