Results 291 to 300 of about 2,111,664 (385)

Elucidating the Molecular Basis in a Cohort of Patients With Combined Bleeding Tendencies and Joint Hypermobility Manifestations

Haemophilia, EarlyView.
ABSTRACT Background In patients with unexplained bleeding and normal haemostatic parameters, heritable disorders of connective tissue (HDCT) may be an underlying cause due to vascular fragility, as observed in Ehlers–Danlos syndrome (EDS) or Marfan syndrome (MS). This study aims to investigate the molecular profile of patients with joint hypermobility (
Perla Bandini, Nina Borràs, Carme Altisent, Judith Sánchez‐Raya, Laura Martin‐Fernandez, Iris Garcia‐Martínez, Natàlia Comes, Lorena Ramírez, Marta Martorell, Carlos Hobeich, Francisco Vidal, Irene Corrales   +11 more
wiley   +1 more source

Low‐Load Quadriceps Strengthening With Blood Flow Restriction in Adults With Haemophilic Knee Arthropathy: A Randomised Controlled Trial

Haemophilia, EarlyView.
Abstract Introduction Haemophilic knee arthropathy leads to a reduction in muscle mass and strength. Blood flow restriction (BFR) involves the application of a compressive cuff that enables strength training with reduced loads. Objective To evaluate safety as the primary outcome and the efficacy (muscle strength and activation, functional capacity and ...
Mar Villalón‐González, Raúl Pérez‐Llanes, José Antonio López‐Pina, Rubén Cuesta‐Barriuso, Elena Donoso‐Úbeda   +4 more
wiley   +1 more source

Evaluating the Safety, Feasibility and Acceptability of Weighted Blankets in Acute Care for People With Dementia: A Randomised Control Trial

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To evaluate the safety, feasibility and acceptability of weighted blankets for patients with dementia who experience agitation in acute care. Design Randomised controlled trial. Methods Patients with dementia experiencing agitation at a single hospital were recruited between May 2023 and January 2024. Participants were randomly assigned to
A. Fox, E. Tomkins, M. Valcovich, E. Ballard   +3 more
wiley   +1 more source

Clinical heterogeneity in vitiligo: Identification of clinical markers based patient clusters

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Vitiligo is a chronic autoimmune disease with heterogeneous clinical presentations. This study analysed 399 patients using hierarchical clustering and identified five phenotypes based on clinical characteristics and lesion distribution. Two groups exhibited high disease activity and extensive involvement.
Laura Galissi, Tristan Benoît, Ribal Merhi, Claire Drullion, Nicolas Andreu, Khaled Ezzedine, Thomas Darde, Katia Boniface, Julien Seneschal   +8 more
wiley   +1 more source

Reliability of Actigraphy for the Assessment of Sleep and Circadian Rhythms in Rett and Related Syndromes

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Purpose Actigraphy is being increasingly used to assess sleep and circadian rhythms among populations with intellectual and developmental disabilities and genetic syndromes, including Rett syndrome and related disorders, but the reliability of these measures in these populations is unclear.
Breanne Byiers, Alyssa Merbler, Elijah Lockhart, Chantel Burkitt, Frank Symons   +4 more
wiley   +1 more source

Anatomical design and production of a novel three‐dimensional co‐culture system replicating the human flexor digitorum profundus enthesis

Journal of Anatomy, EarlyView.
Anatomical morphometrics have been used to design and manufacture models of the flexor digitorum profundus tendon to bone insertion in vitro. This innovative approach can be used to design models of other enthesis regions with anatomical and clinical applicability.
Jeremy W. Mortimer, Philippa A. Rust, Jennifer Z. Paxton   +2 more
wiley   +1 more source

Lawnmower Poetry and the Poetry of Lawnmowers

Critical Quarterly, EarlyView.
Francesca Gardner
wiley   +1 more source

Achilles tenocytes from diabetic and non diabetic donors exposed to hyperglycemia respond differentially to inflammatory stimuli and stretch

Journal of Anatomy, EarlyView.
Scheme depicting the experimental set up of the study. Achilles tendons and tenocytes were isolated from heterozygous (fa/+, non diabetic: non DMT2) and homozygous (fa/fa, diabetic: DMT2) Zucker Diabetic Fatty (ZDF) rats. Tendon degeneration, collagen type 1 alpha 1 chain (COL1A1) and alpha smooth muscle actin (αSMA) expression was determined in rat ...
Nils Fleischmann, Sarah Hofmann, Clemens Gögele, Eva Frank, Christian Werner, Maria Kokozidou, Bernd Hoffmann, Jens Konrad, Gundula Schulze‐Tanzil   +8 more
wiley   +1 more source