Results 21 to 30 of about 102,671 (260)

On Amputation at the Ankle-Joint [PDF]

BMJ
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openaire   +4 more sources

T2* Magnetic Resonance Imaging Uncovers Hemosiderin Burden in Pediatric Hemophilia: A Call for Sensitive Imaging Biomarkers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hemophilic arthropathy remains the leading morbidity in hemophilia despite modern prophylaxis, and early joint damage may be missed by routine exams. This study explored T2* MRI as a noninvasive biomarker of hemosiderin deposition in pediatric hemophilia.
Jessica Garcia, Tarique Hussain, Jeanne Dillenbeck, Matthew Hammer, Annette von Drygalski, Guy Young, Ayesha Zia   +6 more
wiley   +1 more source

Unveiling the role of melatonin‐related gene CSNK1D in osteoclastogenesis and its implications for osteoporosis treatment

Experimental Physiology
Osteoporosis (OP) is a prevalent bone disease characterized by reduced bone density and quality, increasing fragility and fracture risk. Osteoclast (OC) activity and circadian rhythm play a role in the pathogenesis of OP.
Jiewen Zhang, Shaobo Wu, Fangze Xing, Ning Kong, Yiwei Zhao, Xudong Duan, Yiyang Li, Kunzheng Wang, Run Tian, Pei Yang   +9 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Simple geometrical analysis for mechanizing the ankle joint stretching treatment procedure of a PT using a numerical calculation

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2019
In this paper, to mechanize a human ankle joint stretching treatment that is mainly performed by a PT (Physical Therapist), the geometrical relationships among the Ankle joint, Hip joint, Sole, and pushing device rotation center are analyzed using a ...
Hideki TODA, Takeshi MATSUMOTO, Shin SUGIHARA   +2 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Assessing the Ankle Joint Line Level Before and After Total Ankle Arthroplasty With the “Joint Line Height Ratio”

Foot & Ankle Orthopaedics, 2019
Background: Restoring the joint line is an important principle in total knee arthroplasty. However, the effect of joint line level on patient outcomes after total ankle arthroplasty (TAA) remains unclear, as there is no established method for measuring ...
Thos Harnroongroj MD, Amelia Hummel BA, Scott J. Ellis MD, Carolyn M. Sofka MD, Kristin C. Caolo BA, Jonathan T. Deland MD, Constantine A. Demetracopoulos MD   +6 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Joint space width of the tibiotalar joint in the healthy foot

Journal of Foot and Ankle Research, 2015
Background It is important to evaluate dynamic changes in the joint space width of the ankle mortise in detail in order to better understand the pathology of foot and ankle disorders.
Kan Imai, Kazuya Ikoma, Masamitsu Kido, Masahiro Maki, Hiroyoshi Fujiwara, Yuji Arai, Ryo Oda, Daisaku Tokunaga, Nozomu Inoue, Toshikazu Kubo   +9 more
doaj   +1 more source

Biarticular mechanisms of the gastrocnemii muscles enhance ankle mechanical power and work during running

Royal Society Open Science, 2023
The objective of the study was to explore how biarticular mechanisms of the gastrocnemii muscles may provide an important energy source for power and work at the ankle joint with increasing running speed.
Adamantios Arampatzis, Mohamadreza Kharazi, Christos Theodorakis, Falk Mersmann, Sebastian Bohm   +4 more
doaj   +1 more source