Results 11 to 20 of about 118,558 (284)

TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis

Nature Communications, 2021
Ankylosing spondylitis (AS) is a type of rheumatic disease characterized by chronic inflammation and pathological osteogenesis in the entheses. Previously, we demonstrated that enhanced osteogenic differentiation of MSC from AS patients (AS-MSC) resulted
Zhongyu Xie, Wenhui Yu, Guan Zheng, Jinteng Li, Shuizhong Cen, Guiwen Ye, Zhaofeng Li, Wenjie Liu, Ming Li, Jiajie Lin, Zepeng Su, Yunshu Che, Feng Ye, Peng Wang, Yanfeng Wu, Huiyong Shen   +15 more
semanticscholar   +1 more source

A case of ankylosing spondylitis presenting with fever of unknown origin diagnosed as aortitis: A case report

Clinical Case Reports, 2023
Key Clinical Message Clinicians should be aware of rare manifestations of AS, while considering a low threshold for screening vascular involvement in an axial SpA/nrxSpA/AS presenting with unexplained fevers and significant constitutional symptoms and ...
Mahsa Mehdipour Dalivand, Rezvan Abdolazimi, Reyhaneh Manafi‐Farid, Ahmadreza Jamshidi, Kimia Kassaee, Sara Foolad, Majid Alikhani   +6 more
doaj   +1 more source

Inflammasome Activation in Ankylosing Spondylitis Is Associated With Gut Dysbiosis

Arthritis & Rheumatology, 2021
We undertook this study to evaluate the activation and functional relevance of inflammasome pathways in ankylosing spondylitis (AS) patients and rodent models and their relationship to dysbiosis.
G. Guggino, D. Mauro, A. Rizzo, R. Alessandro, S. Raimondo, A. Bergot, M. A. Rahman, J. Ellis, S. Milling, R. Lories, D. Elewaut, Matthew A Brown, Ranjeny Thomas, F. Ciccia   +13 more
semanticscholar   +1 more source

Efficacy and safety of ixekizumab through 52 weeks in two phase 3, randomised, controlled clinical trials in patients with active radiographic axial spondyloarthritis (COAST-V and COAST-W). [PDF]

, 2020
OBJECTIVES: To investigate the efficacy and safety of ixekizumab for up to 52 weeks in two phase 3 studies of patients with active radiographic axial spondyloarthritis (r-axSpA) who were biological disease-modifying antirheumatic drug (bDMARD)-naive ...
Baraliakos, X., Bertram, C.C., Bosch, F. van den, Carlier, H., COAST-V Study Grp, COAST-W Study Grp, Deodhar, A., Dougados, M., Ermann, J., Gallo, G., Gensler, L.S., Heijde, D. van der, Landewe, R., Li, X.Q., Maksymowych, W.P., Sieper, J., Tomita, T., Walsh, J.A., Wei, J.C.C., Zhao, F.Y.   +19 more
core   +3 more sources

Safety and Efficacy of Upadacitinib in Patients With Active Ankylosing Spondylitis and an Inadequate Response to Nonsteroidal Antiinflammatory Drug Therapy: One‐Year Results of a Double‐Blind, Placebo‐Controlled Study and Open‐Label Extension

Arthritis & Rheumatology, 2021
To report the efficacy and safety of upadacitinib through 1 year in patients with ankylosing spondylitis (AS).
A. Deodhar, D. van der Heijde, J. Sieper, F. E. Van den Bosch, W. Maksymowych, Tae-Hwan Kim, M. Kishimoto, A. Ostor, B. Combe, Y. Sui, A. Chu, I. Song   +11 more
semanticscholar   +1 more source

Relationship between smoking, clinical, inflammatory, and radiographic parameters in patients with ankylosing spondylitis

Egyptian Rheumatology and Rehabilitation, 2021
Background Ankylosing spondylitis (AS) is an autoimmune multisystemic disease that attacks the spine, sacroiliacs, and often causes asymmetrical peripheral oligoarthritis. It results from the interaction between the genetic factors mainly Human Leukocyte
Hanan M. Farouk, Maryam A. Abdel-Rahman, Rasha Mohamad Hassan   +2 more
doaj   +1 more source

Disease and psychological status in ankylosing spondylitis. [PDF]

, 2006
Objectives. Psychological factors may be important in the assessment and management of ankylosing spondylitis (AS). Our primary objective was to describe associations between disease and psychological status in AS, using AS-specific assessment tools and ...
Goodacre, J. A., Goodacre, L., Grennan, D., Martindale, J., Smith, J., Sutton, Chris J   +5 more
core   +1 more source

Nonsteroidal anti-inflammatory drugs: a basis for the treatment of ankylosing spondylitis

Современная ревматология, 2011
The paper describes the pathomorphological aspects of ankylosing spondylitis (AS) and the value of nonsteroidal anti-inflammatory drugs in its therapy. Clinical trials demonstrate the high efficacy of aceclofenac (aertal) in AS.
A A Godzenko
doaj   +1 more source

A new and spontaneous animal model for ankylosing spondylitis is found in cynomolgus monkeys

Arthritis Research & Therapy, 2022
Background Ankylosing spondylitis is a progressive, disabling joint disease that affects millions worldwide. Given its unclear etiology, studies of ankylosing spondylitis relied heavily on drug-induced or transgenic rodent models which retain only ...
Huanhuan Jia, Meili Chen, Yanzhen Cai, Xiaoling Luo, Gang Hou, Yongfeng Li, Chunmei Cai, Jun Chen, Qingnan Li, Kai-Kei Miu, Sin-Hang Fung, Zhangting Wang, Ren Huang, Huiyong Shen, Li Lu   +14 more
doaj   +1 more source

Increased Risk of Common Orthopedic Surgeries for Patients with Rheumatic Diseases in Taiwan

Medicina, 2022
Background and Objectives: Rheumatic diseases, including rheumatoid arthritis, ankylosing spondylitis, psoriasis, and systemic lupus erythematosus (SLE), are characterized by chronic arthritis or spondyloarthritis, which can lead to joint and spine ...
Min-Chih Hsieh, Malcolm Koo, Chia-Wen Hsu, Ming-Chi Lu   +3 more
doaj   +1 more source