Results 211 to 220 of about 136,777 (328)

Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

open access: yesPharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disorder, recognized as the most prevalent form of dementia. It is characterized by multiple pathological processes, including amyloid‐beta accumulation, neurofibrillary tangles, and neuroinflammation. The therapeutic efficacy of traditional single‐target drugs has been
Md Saad Hossain, Md Hamed Hussain
wiley   +1 more source

Prescribing Inflammatory Bowel Disease Medications in Chronic Kidney Disease: A Practical Guide

open access: yesAlimentary Pharmacology &Therapeutics, Volume 62, Issue 4, Page 400-418, August 2025.
Most therapies used in inflammatory bowel disease appear safe and effective when used in chronic kidney disease including on renal replacement therapy, particularly biologic therapies. Some caution should be considered when using conventional therapies and JAK inhibitors.
Lynna Chen   +6 more
wiley   +1 more source

Comparison of Biportal Endoscopic Technique and Conventional Unilateral Laminectomy for Bilateral Decompression (ULBD) for Multi‐Level Degenerative Lumbar Spinal Stenosis in Elderly People

open access: yesOrthopaedic Surgery, Volume 17, Issue 8, Page 2302-2312, August 2025.
The red line on the left and the blue line on the right represent the surgical field of view for BE‐ULBD and ULBD surgeries, respectively. It can be seen that BE‐ULBD significantly enhances the surgical field of view and makes it easier to expose the contralateral nerve root.
Chenhao Dou   +4 more
wiley   +1 more source

Decrease in Global Offset Leads to Complaints of Worsening of Valgus Knee Deformity After Total Hip Arthroplasty in Patients With Crowe Type IV Developmental Dysplasia of the Hip

open access: yesOrthopaedic Surgery, Volume 17, Issue 8, Page 2281-2290, August 2025.
The decrease in global offset could lead to an increase in the tibial joint line angle, suggesting pseudoprogression of the valgus knee deformity and thereby causing complaints of its worsening. ABSTRACT Background Conflicting evidence exists regarding the impact of total hip arthroplasty (THA) on valgus knee deformities in patients with developmental ...
Minzhi Yang   +4 more
wiley   +1 more source

Is Collum Femoris Preserving Stem (CFP) an Epiphyseal‐Stabilized Prosthesis? A Long‐Term Single‐Center Series Follow Up of 705 Cases

open access: yesOrthopaedic Surgery, Volume 17, Issue 8, Page 2385-2396, August 2025.
The Collum Femoris Preserving (CFP) stem, designed to minimize stress shielding and preserve femoral neck bone stock, demonstrated a 95.32% long‐term survival rate over 10.4 years. Radiographic findings revealed significant proximal femoral bone resorption and distal femoral sclerosis, redefining CFP stems as distal‐stabilized rather than epiphyseal ...
Yansong Liu   +5 more
wiley   +1 more source

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