Results 31 to 40 of about 136,777 (328)

New developments in our understanding of ankylosing spondylitis pathogenesis

Immunology, 2020
Ankylosing spondylitis (AS) is a common immune‐mediated inflammatory arthritis with a strong genetic predisposition. We review recent data from genetic and animal studies highlighting the importance of Type 17 immune responses. Furthermore, the efficacy (
Aniruddha Voruganti, P. Bowness
semanticscholar   +1 more source

Whole body MR imaging in ankylosing spondylitis: a descriptive pilot study in patients with suspected early and active confirmed ankylosing spondylitis

BMC Musculoskeletal Disorders, 2007
Background Ankylosing spondylitis is a chronic inflammatory rheumatic disorder which usually begins in early adulthood. The diagnosis is often delayed by many years.
Hodler Juerg, Kissling Rudolf O, Pfirrmann Christian WA, Weber Ulrich, Zanetti Marco   +4 more
doaj   +1 more source

Scotland Registry for Ankylosing Spondylitis (SIRAS) – Protocol [PDF]

, 2016
Funding SIRAS was funded by unrestricted grants from Pfizer and AbbVie. The project was reviewed by both companies, during the award process, for Scientific merit, to ensure that the design did not compromise patient safety, and to assess the global ...
Dean, Linda E, Gibson, Jane, Hunter, John, Jones, Elizabeth A, Jones, Gareth T, MacDonald, Alan G, Macfarlane, Gary J, Marshall, David, McEntegart, Anne, Munro, Robin, Sturrock, Roger D   +10 more
core   +1 more source

2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis

Arthritis care & research, 2019
To update evidence‐based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA).
M. Ward, A. Deodhar, L. Gensler, M. Dubreuil, David T. Y. Yu, M. Khan, N. Haroon, D. Borenstein, Runsheng Wang, A. Biehl, M. Fang, G. Louie, V. Majithia, B. Ng, Rosemary Bigham, Michael Pianin, A. A. Shah, Nancy M. Sullivan, Marat Turgunbaev, J. Oristaglio, Amy S. Turner, W. Maksymowych, L. Caplan   +22 more
semanticscholar   +1 more source

Association of Secukinumab Treatment With Tuberculosis Reactivation in Patients With Psoriasis, Psoriatic Arthritis, or Ankylosing Spondylitis

JAMA dermatology, 2020
This pooled cohort study evaluates the safety of newer biological agents for the treatment of tuberculosis infection and activation in patients with psoriasis, psoriatic arthritis, and ankylosing spondylitis.
B. Elewski, J. Baddley, A. Deodhar, M. Magrey, P. Rich, E. Soriano, J. Soung, W. Bao, D. Keininger, K. Marfo, M. Patekar, Abhishek Sharma, A. Shete, M. Lebwohl   +13 more
semanticscholar   +1 more source

HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis

Frontiers in Cell and Developmental Biology, 2021
Statins are an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). Growing evidence indicates that statins may have an anti-inflammatory effect.
Zhenyu Zhong, Xiaojie Feng, Guannan Su, Liping Du, Weiting Liao, Shengyun Liu, Fuzhen Li, Xianbo Zuo, Peizeng Yang   +8 more
doaj   +1 more source

Clinical and MRI responses to etanercept in early non-radiographic axial spondyloarthritis : 48-week results from the EMBARK study [PDF]

, 2015
Objective: To evaluate the efficacy and safety of etanercept (ETN) after 48 weeks in patients with early active non-radiographic axial spondyloarthritis (nr-axSpA).
Bonin, Randi, Braun, Jürgen, Bukowski, Jack F, Citera, Gustavo, Dougados, Maxime, Jones, Heather, Kotak, Sameer, Logeart, Isabelle, Maksymowych, Walter P, Marshall, Lisa, Pedersen, Ron, Sieper, Joachim, Van den Bosch, Filip, van der Heijde, Désirée, Vlahos, Bonnie, Wajdula, Joseph   +15 more
core   +1 more source

Birth Outcomes and Disease Activity During Pregnancy in a Prospective Cohort of Women With Psoriatic Arthritis and Ankylosing Spondylitis

Arthritis care & research, 2020
To add to data on adverse birth outcomes accounting for disease activity in women with psoriatic arthritis (PsA) and ankylosing spondylitis (AS).
Chelsey J. F. Smith, G. Bandoli, A. Kavanaugh, C. Chambers   +3 more
semanticscholar   +1 more source

Common MIR146A Polymorphisms in Chinese Ankylosing Spondylitis Subjects and Controls. [PDF]

PLoS ONE, 2015
Common polymorphisms of microRNA gene MIR146A were reported as associated with different autoimmune diseases, include systemic lupus erythematosus, psoriatic arthritis, asthma and ankylosing spondylitis.
Zhenmin Niu, Jiucun Wang, Hejian Zou, Chengde Yang, Wei Huang, Li Jin   +5 more
doaj   +1 more source

Ankylosing Spondylitis: a trade Off of HLA-B27, ERAP, and pathogen interconnections? Focus on Sardinia [PDF]

, 2019
The frequency of HLA-B27 in patients with Ankylosing Spondylitis (AS) is over 85%. There are more than 170 recognized HLA-B27 alleles but the majority of them is not sufficiently represented for genetic association studies.
Cauli, A, Fiorillo, Mt, Mathieu, A, Paladini, F, Sorrentino, R., Tedeschi, V   +5 more
core   +2 more sources