Results 1 to 10 of about 258,529 (142)

Correspondence: Acute Lymphoblastic Leukaemia and HbE-alpha Thalassaemia. [PDF]

J Clin Diagn Res, 2016
Sir, The recent report on “Acute Lymphoblastic Leukaemia and HbE-alpha Thalassaemia” is very interesting [1]. Rajendran et al., presented a case study and mentioned that “though malignancies are one of the complications in thalassaemia, occurrence of ...
Yasri S, Wiwanitkit V.
europepmc   +2 more sources

Cerebral Blood Flow Is Associated with Diagnostic Class and Cognitive Decline in Alzheimer’s Disease

Journal of Alzheimer's Disease, 2020
Background: Reliable cerebral blood flow (CBF) biomarkers using a noninvasive imaging technique are sought to facilitate early diagnosis and intervention in early Alzheimer’s disease (AD).
Wenna Duan, Parshant Sehrawat, Arvind Balachandrasekaran, Ashish B Bhumkar, Paresh B Boraste, J. Becker, L. Kuller, O. Lopez, H. Gach, W. Dai   +9 more
semanticscholar   +1 more source

Parkinson’s Disease Drug Therapies in the Clinical Trial Pipeline: 2023 Update

Journal of Parkinson's Disease, 2023
Background: Since 2020, annual reports on the clinical development of new drug-based therapies for the neurodegenerative condition of Parkinson’s disease (PD) have been generated. These reviews have followed the progress of both “symptomatic treatments” (
K. McFarthing, Sue Buff, Gary Rafaloff, B. Fiske, Leah R Mursaleen, Rosie Fuest, R. Wyse, S. Stott   +7 more
semanticscholar   +1 more source

Pulmonary Vasodilator Therapy in Severe Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease (Severe PH-COPD): A Systematic Review and Meta-Analysis

Journal of Cardiovascular Development and Disease, 2023
Background: Chronic obstructive pulmonary disease-associated pulmonary hypertension (PH-COPD) results in a significant impact on symptoms, quality of life, and survival. There is scant and conflicting evidence about the use of pulmonary hypertension (PH)
A. Elkhapery, M. Hammami, R. Sulica, H. Boppana, Zeinab Abdalla, Charoo Iyer, Hazem Taifour, Chengu Niu, H. Deshwal   +8 more
semanticscholar   +1 more source

Consistency between Treatment Effects on Clinical and Brain Atrophy Outcomes in Alzheimer’s Disease Trials

The journal of prevention of Alzheimer's disease, 2023
Background Longitudinal changes in volumetric MRI outcome measures have been shown to correlate well with longitudinal changes in clinical instruments and have been widely used as biomarker outcomes in clinical trials for Alzheimer’s disease (AD).
M. ten Kate, F. Barkhof, Adam J. Schwarz
semanticscholar   +1 more source

Definitions of resilience and resilience resource use as described by adults with congenital heart disease

International Journal of Cardiology Congenital Heart Disease, 2023
Structured Abstract Background Adult congenital heart disease (ACHD) is a lifelong illness that presents ongoing challenges to quality of life. Fostering personal resilience resources to sustain well-being can enhance patients’ psychosocial health ...
J. Steiner, Erin Abu-Rish Blakeney, Andrea Corage Baden, Vea Freeman, Joyce P. Yi-Frazier, J. Curtis, R. Engelberg, A. Rosenberg   +7 more
semanticscholar   +1 more source

Parkinson’s Disease Drug Therapies in the Clinical Trial Pipeline: 2022 Update

Journal of Parkinson's Disease, 2022
Background: As the international community dealt with the ongoing COVID-19 pandemic, important progress continued to be made in the development of new drug-based therapies for the neurodegenerative condition of Parkinson’s disease (PD) in 2021.
K. McFarthing, Gary Rafaloff, Marco A. S. Baptista, Leah R Mursaleen, Rosie Fuest, R. Wyse, S. Stott   +6 more
semanticscholar   +1 more source

Cerebral Gray and White Matter Monogalactosyl Diglyceride Levels Rise with the Progression of Alzheimer’s Disease

Journal of Alzheimer's Disease, 2023
Background: Multiple studies have reported brain lipidomic abnormalities in Alzheimer’s disease (AD) that affect glycerophospholipids, sphingolipids, and fatty acids.
Jan Krzysztof Blusztajn, Nurgul Aytan, Thekkelnaycke M. Rajendiran, Tiffany J Mellott, Tanu Soni, C. Burant, G. Serrano, T. Beach, Honghuang Lin, T. Stein   +9 more
semanticscholar   +1 more source

Sorting of chromosomes by magnetic separation [PDF]

, 1988
Chromosomes were isolated from Chinese hamster x human hybrid cell lines containing four and nine human chromosomes. Human genomic DNA was biotinylated by nick translation and used to label the human chromosomes by in situ hybridization in suspension ...
A Oberteufer, B Schw�ger, B Trask, C Cremer, Christoph Cremer, CS Owen, D Durnam, D Peters, D Pinkel, D Pinkel, Eduardo Diaz, Ernst W. Steegmayer, G Dudin, Gertrud Dudin, Haide Schnitzer, JC Fuscoe, JG Collard, K Nustad, Kathryn E. Howell, KE Howell, L Manuelidis, L-C Yu, M Schardin, Peter Vogt, PW Rigby, RS Molday, RV Lebo, T Lea, T Lea, Thomas Cremer, U Blochmann   +30 more
core   +1 more source

METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial–mesenchymal transition of renal tubular cells in diabetic kidney disease

Cell Death and Disease, 2021
Histone deacetylase 5 (HDAC5) belongs to class II HDAC subfamily and is reported to be increased in the kidneys of diabetic patients and animals. However, little is known about its function and the exact mechanism in diabetic kidney disease (DKD).
Zhaoxia Xu, Keqi Jia, Hui Wang, F. Gao, Song Zhao, Fan Li, Jun Hao   +6 more
semanticscholar   +1 more source