Results 11 to 20 of about 258,567 (178)

Decoding the Implications of Zinc in the Development and Therapy of Leukemia. [PDF]

Adv Sci (Weinh)
Zinc's pivotal role in hematological development and its therapeutic potential in leukemia are explored. This review delves into the complex interplay of zinc signaling in leukemia progression and treatment. It highlights recent advancements, such as zinc's regulation of ferroptosis and its impact on immunotherapy, underscoring the need for zinc‐based ...
Zhu B, Yang C, Hua S, Li K, Shang P, Li Z, Qian W, Xue S, Zhi Q, Hua Z.   +9 more
europepmc   +2 more sources

Central nervous system Aspergillus quadrilineatus infection in a COVID‐19 patient, a case report and literature review

Journal of Clinical Laboratory Analysis, Volume 37, Issue 19-20, October 2023., 2023
The first COVID‐19‐associated cerebral aspergillosis was due to Aspergillus quadrilineatus in a pediatric patient with acute lymphocytic leukemia. A combination of intravenous liposomal amphotericin B and caspofungin therapy for 8 days, did not improve the patient's condition. The patient gradually continued to deteriorate and expired.
Kazem Amirizad, Mona Ghazanfari, Javad Javidnia, Mahdi Abastabar, Mohammad Taghi Haghi Ashtiani, Maryam Sotoudeh Anvari, Maryam Fathi, Amirreza Espahbodi, Hamid Badali, Mohammad Taghi Hedayati, Iman Haghani, Seyedmojtaba Seyedmousavi   +11 more
wiley   +1 more source

Metabolic syndrome as a late effect of childhood hematopoietic stem cell transplantation – A thorough statistical evaluation of putative risk factors

Pediatric Transplantation, Volume 27, Issue 4, June 2023., 2023
Abstract Background Metabolic syndrome (MetS) is frequent among survivors of childhood hematopoietic stem‐cell transplantation (HSCT), but assessment of risk factors is challenged by survivor and participation bias in long‐term follow‐up studies. Methods A cohort of 395 pediatric patients transplanted between 1980 and 2018 was investigated.
Tina Gerbek, Birthe Lykke Thomsen, Ena Muhic, Terkel Christiansen, Kaspar Sørensen, Marianne Ifversen, Klaus Kofoed, Klaus Müller   +7 more
wiley   +1 more source

Increased survival disparities among children and adolescents & young adults with acute myeloid leukemia: A Dutch population‐based study

International Journal of Cancer, Volume 150, Issue 7, Page 1101-1112, April 1, 2022., 2022
What's new? For many cancers, children under 18 have better survival outcomes than adolescents and young adults, age 18‐39. Here, the authors evaluated long‐term survival of young people diagnosed with acute myeloid leukemia in the Netherlands. When they compared outcomes, they found that adolescents and young adults had a worse prognosis than children.
Maya Schulpen, Bianca F. Goemans, Gertjan J. L. Kaspers, Marc H. G. P. Raaijmakers, C. Michel Zwaan, Henrike E. Karim‐Kos   +5 more
wiley   +1 more source

Hematologic malignancy in tanker crewmembers: A case‐referent study among male Swedish seafarers

American Journal of Industrial Medicine, Volume 63, Issue 8, Page 685-692, August 2020., 2020
Abstract Background Work on Swedish petroleum tankers before the late 1980s has been associated with an increased risk of hematologic malignancy (HM). Since then, ship modernizations have decreased occupational exposure to gases, including the carcinogen benzene. We explored the risk of HMs in Swedish seafarers who had worked on newer types of tankers.
Karl Forsell, Ove Björ, Bengt Järvholm, Ralph Nilsson, Eva Andersson   +4 more
wiley   +1 more source

Insights into the multifaceted role of circular RNAs: implications for Parkinson’s disease pathogenesis and diagnosis

npj Parkinson's Disease, 2022
Parkinson’s disease (PD) is a complex, age-related, neurodegenerative disease whose etiology, pathology, and clinical manifestations remain incompletely understood. As a result, care focuses primarily on symptoms relief.
E. Doxakis
semanticscholar   +1 more source

Causes of early death and treatment‐related death in newly diagnosed pediatric acute myeloid leukemia: Recent experiences of the Dutch Childhood Oncology Group

Pediatric Blood &Cancer, Volume 67, Issue 4, April 2020., 2020
Abstract Background With the current more effective treatment regimens for pediatric acute myeloid leukemia (AML), research on early death (ED), treatment‐related mortality (TRM), and toxicity becomes increasingly important. The aim of this study was to give an overview of the frequency, clinical features, and risk factors associated with ED and TRM in
Kim Klein, Raphaële R.L. van Litsenburg, Valérie de Haas, Natasja Dors, Marry M. van den Heuvel‐Eibrink, Rutger R.G. Knops, Wim J.E. Tissing, Birgitta A. Versluys, C. Michel Zwaan, Gertjan J.L. Kaspers   +9 more
wiley   +1 more source

Occupational Class and Risk of Cardiovascular Disease Incidence in Japan: Nationwide, Multicenter, Hospital‐Based Case‐Control Study

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2019
Background In contemporary Western settings, higher occupational class is associated with lower risk for cardiovascular disease (CVD) incidence, including coronary heart disease (CHD) and stroke.
M. Zaitsu, Soichiro Kato, Yongjoo Kim, T. Takeuchi, Yuzuru Sato, Yasuki Kobayashi, I. Kawachi   +6 more
semanticscholar   +1 more source

Regulation of the Late Onset alzheimer’s Disease Associated HLA-DQA1/DRB1 Expression

American Journal of Alzheimers Disease & Other Dementias, 2022
(Genome-wide Association Studies) GWAS have identified ∼42 late-onset Alzheimer’s disease (LOAD)-associated loci, each of which contains multiple single nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD) and most of these SNPs are in the non ...
Xiaoyu Zhang, Mei‐Juan Zou, Yuwei Wu, Danli Jiang, Ting Wu, Yihan Zhao, Di Wu, J. Cui, Gang Li   +8 more
semanticscholar   +1 more source

Elevation of gangliosides in four brain regions from Parkinson’s disease patients with a GBA mutation

npj Parkinson's Disease, 2022
A number of genetic risk factors have been identified over the past decade for Parkinson’s Disease (PD), with variants in GBA prominent among them. GBA encodes the lysosomal enzyme that degrades the glycosphingolipid, glucosylceramide (GlcCer), with the ...
Shani Blumenreich, Tamar Nehushtan, Or B. Barav, Jennifer T. Saville, T. Dingjan, J. Hardy, M. Fuller, A. Futerman   +7 more
semanticscholar   +1 more source