Results 21 to 30 of about 258,567 (178)
Journal of Alzheimer's Disease, 2021 Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and the most common type of dementia. A growing body of evidence has implicated neuroinflammation as an essential player in the etiology of AD.
R. Kuwar +8 more
semanticscholar +1 more source
Parkinson’s Disease Drug Therapies in the Clinical Trial Pipeline: 2021 Update
Journal of Parkinson's Disease, 2021 Background: Despite the COVID-19 pandemic, there has been considerable activity in the clinical development of novel and improved drug-based therapies for the neurodegenerative condition of Parkinson’s disease (PD) during 2020.
K. McFarthing +4 more
semanticscholar +1 more source
Class-Specific Incidence of All-Cause Dementia and Alzheimer’s Disease: A Latent Class Approach
Journal of Alzheimer's Disease, 2018 Identifying preclinical Alzheimer’s disease (AD) is an important step toward developing approaches to early treatment and dementia prevention. We applied latent class analysis (LCA) to 10 baseline neuropsychological assessments for 1,345 participants ...
Andrea R. Zammit +6 more
semanticscholar +1 more source
In vitro characterization of rat bone marrow-derived dendritic cells and their precursors [PDF]
, 1996 Although the rat is commonly used for basic immunology and transplantation research, phenotypic and functional characterization of rat dendritic cells (DCs) lags behind similar studies in the human and mouse. Therefore, these features were examined using
Chen-Woan, M +7 more
core +1 more source
Lipids in Health and Disease, 2016 Several single nucleotide polymorphisms (SNPs) in lipid transport genes have been shown to be associated with premature coronary artery disease (PCAD). The scavenger receptor BI (SCARB1) is a key component of the reverse cholesterol transport and lipid ...
H. Goodarzynejad +4 more
semanticscholar +1 more source
Neuronal Presentation of Antigen and Its Possible Role in Parkinson’s Disease
Journal of Parkinson's Disease, 2022 Patients with Parkinson’s disease (PD) and other synucleinopathies often exhibit autoimmune features, including CD4+ and some CD8+ T lymphocytes that recognize epitopes derived from alpha-synuclein.
Benjamin D. Hobson, D. Sulzer
semanticscholar +1 more source
DY determinants, possibly associated with novel class II molecules, stimulate autoreactive CD4+ T cells with suppressive activity [PDF]
, 1988 A set of T cell clones (TCC) isolated from HLA-DR-, Dw-, DQ-matched allogeneic MLCs was found to proliferate autonomously when stimulated with cells carrying a wide range of class I or II specificities.
Brocker, Thomas +5 more
core +2 more sources
Childhood cancer incidence and survival in Japan and England: A population‐based study (1993‐2010)
Cancer Science, Volume 109, Issue 2, Page 422-434, February 2018., 2018 For many of childhood cancers, 5‐year survival improved in Japan and England. The improvement in survival in chronic myeloid leukaemia (CML) was particularly dramatic in both countries. The present study aimed to compare cancer incidence and trends in survival for children diagnosed in Japan and England, using population‐based cancer registry data. The
Kayo Nakata +9 more
wiley +1 more source
Journal of Thyroid Research, Volume 2018, Issue 1, 2018., 2018 Increased risk of second primary malignancy (SPM) in papillary thyroid cancer (PTC) has been reported. Here, we present the most updated incidence rates of second primary malignancy from original diagnosis of PTC by using the data from the Surveillance, Epidemiology, and End Results.
Mayumi Endo +4 more
wiley +1 more source