Results 191 to 200 of about 540,738 (249)

An Attempt to Fathom the Role of Annotations in User-Centered Design Process

, 2019
Jean-Luc Hak, Olivier Nicolas, Marco Winckler, Philippe Palanque   +3 more
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Towards Automated Reporting: A Bronchoscopy Report Dataset for Enhancing Multimodality Large Language Models. [PDF]

Sci Data
Luo X, Huang X, Liang X, Wang J, Gu J, Yi D, Zhao H, Zhang H, Wu J, Lei Z, Meng G, Ren H, Luo J, Liao H, Liu H.   +14 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Transformer-based relation extraction and concept normalization using an annotated clinical trials corpus. [PDF]

Sci Data
Campillos-Llanos L, Valverde-Mateos A, Capllonch-Carrión A, González-Quevedo D, López-Urbán MR, Hernando-Tundidor MS, Zakhir-Puig S, Heras J.   +7 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Comprehensive annotation of the enzymes of Drosophila melanogaster. [PDF]

G3 (Bethesda)
Garapati PV, Zaru R, Attrill H, Dos Santos G, Goodman J, Thurmond J, Marygold SJ.   +6 more
europepmc   +1 more source

Additional file 2: of De-novo transcriptome assembly for gene identification, analysis, annotation, and molecular marker discovery in Onobrychis viciifolia

, 2016
Marina Mora-Ortiz, Martin Swain, Martin Vickers, Matthew Hegarty, Rhys Kelly, Lydia Smith, Leif SkĂ ̧T   +6 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases. [PDF]

PLoS Comput Biol
Ticó M, Sullivan E, Guigó R, Mariotti M.   +3 more
europepmc   +1 more source