Results 191 to 200 of about 1,137,186 (320)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
ATEdrug: A reliable human-in-the-loop annotation scheme for aspect term extraction and polarity detection in drug reviews. [PDF]
Ansari G +5 more
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The plant transcriptome – from integrating observations to models
Alisdair eFernie, Bjoern eUsadel
doaj +1 more source
AICellType: a large language model-based platform for accurate cell type annotation. [PDF]
Cheng C +6 more
europepmc +1 more source
De novo transcriptome assembly and its annotation for the black ant Formica fusca at the larval stage [PDF]
Claire Morandin +3 more
openalex +1 more source

