Results 71 to 80 of about 15,838 (216)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

An experimental study of rotational pressure loss in rotor-stator gap

Propulsion and Power Research, 2017
The annular gap between rotor and stator is an inevitable flow path of a throughflow ventilated electrical machine, but the flow entering the rotor-stator gap is subjected to the effects of rotation.
Yew Chuan Chong, Dave A. Staton, Markus A. Mueller, John Chick   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Free In-Plane Vibration Analysis of Circular, Annular, and Sector Plates Using Isogeometric Approach

Shock and Vibration, 2018
The in-plane free vibration of sector, annular, and circular plates is investigated by isogeometric finite element approach on the basis of nonuniform rational B-spline (NURBS) basis functions. Under the current framework, both the displacement field and
Xiaohui Qin, Guoyong Jin, Mingfei Chen, Shaoping Yin   +3 more
doaj   +1 more source

Spectral method for identification of flow regimes in a Couette-Taylor annular flow [PDF]

E3S Web of Conferences
The paper presents a study of flow structure in an annular flow of the Couette-Taylor system, employing spectral analysis of moment of resistance and radial dynamic pressure pulsations. Experiments were conducted on a model featuring a single annular gap,
Miskiv Nikolay, Mamonov Valeriy, Nazarov Alexander, Serov Anatoliy, Terekhov Victor   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Analysis of the effect of steam injection conditions on the integrity of casing-cement sheath-formation assemblies in heavy oil thermal recovery

Petroleum
Accurately forecasting the sealing failure behavior of the casing-cement sheath-formation assembly under various steam injection operational parameters and cyclic steam stimulation conditions remains challenging.
Fuquan Ding, Huajie Liu, Zhongguang Liu, Yuhuan Bu, Hongxu Zhang, Hui Yin   +5 more
doaj   +1 more source