Results 261 to 270 of about 307,816 (329)

Amyloid Forming Human Lysozyme Intermediates are Stabilized by Non‐Native Amide‐π Interactions

open access: yesAdvanced Science, EarlyView.
Mutational variants of human lysozyme cause fatal systemic amyloidosis by depositing kilograms of protein in the viscera of patients. Central to this process is a partially unfolded protein intermediate state that initiates aggregation into amyloid fibrils.
Minkoo Ahn   +6 more
wiley   +1 more source

ATM Anomaly Detection

open access: yesInternational Journal for Research in Applied Science and Engineering Technology, 2020
openaire   +1 more source

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways

open access: yesAdvanced Science, EarlyView.
EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen   +12 more
wiley   +1 more source

PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects

open access: yesAdvanced Science, EarlyView.
PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li   +6 more
wiley   +1 more source

Artificial Room‐Temperature Ferromagnetism of Bulk van der Waals VSe2

open access: yesAdvanced Science, EarlyView.
Artificial room‐temperature vdW ferromagnetism of bulk VSe2 has been presented via nano‐crystallization. By constructing the MFM junction with nano‐crystallized VSe2, vdW ferromagnetism has been spatially resolved with a ferromagnetic hysteresis curve.
Jinhyoung Lee   +28 more
wiley   +1 more source

Q‐GEM: Quantum Chemistry Knowledge Fusion Geometry‐Enhanced Molecular Representation for Property Prediction

open access: yesAdvanced Science, EarlyView.
This work introduces E‐GeoGNN, a graph neural network framework that systematically encodes molecular structural information through three hierarchical correlation graphs: atom‐bond graph, bond‐angle graph, and angle‐dihedral graph. By incorporating quantum and geometric dual‐scale self‐supervised pretraining, Q‐GEM is proposed, a novel molecular ...
Zhijiang Yang   +7 more
wiley   +1 more source

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