Results 41 to 50 of about 54,372 (262)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Utility-preserving anonymization for health data publishing

BMC Medical Informatics and Decision Making, 2017
Background Publishing raw electronic health records (EHRs) may be considered as a breach of the privacy of individuals because they usually contain sensitive information.
Hyukki Lee, Soohyung Kim, Jong Wook Kim, Yon Dohn Chung   +3 more
doaj   +1 more source

Preserving Both Privacy and Utility in Network Trace Anonymization

, 2018
As network security monitoring grows more sophisticated, there is an increasing need for outsourcing such tasks to third-party analysts. However, organizations are usually reluctant to share their network traces due to privacy concerns over sensitive ...
Adam, Beale Jay, Boldyreva Alexandra, Borisov Nikita, Chenette Nathan, Chenette Nathan, Computer Science Private, Differential, Gummadi P. Krishna, Kit Wai, Mivule K., Ny Le, Ostrovsky Rafail, Ribeiro B., Sahai Amit, Scott, Slagell A.J., Villani Antonio, Wang Jun, Xiaoding Dawn, Xu J., Yurcik W., Årnes André   +22 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Addressing challenges in speaker anonymization to maintain utility while ensuring privacy of pathological speech

Communications Medicine
Background Integration of speech into healthcare has intensified privacy concerns due to its potential as a non-invasive biomarker containing individual biometric information.
Soroosh Tayebi Arasteh, Tomás Arias-Vergara, Paula Andrea Pérez-Toro, Tobias Weise, Kai Packhäuser, Maria Schuster, Elmar Noeth, Andreas Maier, Seung Hee Yang   +8 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Archival, anonymization and presentation of HTCondor logs with GlideinMonitor [PDF]

, 2021
Marco Mambelli, Mirica Yancey, Thomas Hein   +2 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Segmentation stability of human head and neck cancer medical images for radiotherapy applications under de-identification conditions: Benchmarking data sharing and artificial intelligence use-cases

Frontiers in Oncology, 2023
BackgroundDemand for head and neck cancer (HNC) radiotherapy data in algorithmic development has prompted increased image dataset sharing. Medical images must comply with data protection requirements so that re-use is enabled without disclosing patient ...
Jaakko Sahlsten, Kareem A. Wahid, Enrico Glerean, Joel Jaskari, Mohamed A. Naser, Renjie He, Benjamin H. Kann, Antti Mäkitie, Clifton D. Fuller, Kimmo Kaski   +9 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source