Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, Volume 600, Issue 2, Page 239-250, January 2026.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection
PLoS Pathogens, 2018 Plasmodium relies on numerous agonists during its journey through the mosquito vector, and these agonists represent potent targets for transmission-blocking by either inhibiting or interfering with them pre- or post-transcriptionally.
Yuemei Dong +3 more
semanticscholar +1 more source
Variation in Pyrethroid Resistance Phenotypes in Anopheles darlingi in an Area with Residual Malaria Transmission: Warning of Suspected Resistance in French Guiana [PDF]
, 2022 Samuel B Vezenegho +12 more
openalex +1 more source
Cryopreservation of Anopheles gambiae Larvae
Advanced Biology, Volume 10, Issue 1, January 2026.Advancements in vector control methods have resulted in a rapidly growing collection of critically important mosquito strains necessitating the development of cryopreservation protocols to minimize the risk of genetic drift, cross‐contamination, or catastrophic loss.
Purva Joshi +7 more
wiley +1 more source
Revista de Saúde PúblicaA relation between a rice irrigation system and mosquito breeding was established in a study undertaken at the Ribeira Valley Experimental Station, from January through December 1992.
Oswaldo Paulo Forattini +3 more
doaj
Insect I‐Type Lysozymes Function as Antiviral Proteases by Forming Biomolecular Condensates
Advanced Science, Volume 13, Issue 1, 5 January 2026.Upon rice viral infection, the insect vector activates the Toll–MyD88–Dorsal signaling cascade, inducing i‐type lysozyme (Lyz‐I1) expression. Lyz‐I1 functions as an antiviral protease through its conserved catalytic dyad Glu/Asp (E/D), mediating cleavage of viral proteins at specific Lys (K) residues.
Yu Du +5 more
wiley +1 more source
Ecologies of Risk: Malaria and Settler Landscape Transformation in 19th‐Century Ontario
American Journal of Human Biology, Volume 38, Issue 1, January 2026.ABSTRACT Objectives This study examines how settler‐driven environmental change shaped malaria transmission and mortality in 19th‐century southern Ontario. It aimed to understand the biosocial and ecological conditions that sustained endemic malaria in a temperate, colonial context.
Amanda Cooke, Megan B. Brickley
wiley +1 more source
Scent Goes Digital: The Role of Insect Odorant Binding Proteins in Modern Technology
BioFactors, Volume 52, Issue 1, January/February 2026.This review delves into bioinspired olfactory biosensors, focusing on insect odorant binding proteins (OBPs) as core elements of hybrid bionic platforms for volatile compound detection. Highlighting the development of the biological electronic nose (BE‐NOSE), it examines current prototypes, outlines advantages over conventional methods, and explores ...
Maddalena Ventura +5 more
wiley +1 more source
Paridade e desenvolvimento ovariano de Anopheles albitarsis l.s. em área de agroecossistema irrigado
Revista de Saúde PúblicaOBJETIVO: Conhecer a paridade, o desenvolvimento ovariano e a razão de sobrevivência da espécie Anopheles albitarsis, visando a estimar o potencial de transmissão malárica.
Iná Kakitani, Oswaldo Paulo Forattini
doaj