Results 41 to 50 of about 2,420 (127)

Widespread occurrence of copy number variants and fixation of pyrethroid target site resistance in Anopheles gambiae (s.l.) from southern Côte d’Ivoire

Current Research in Parasitology and Vector-Borne Diseases, 2023
Resistance to pyrethroid and organophosphate insecticides in the malaria vector Anopheles gambiae (s.l.) is conferred by a variety of genetic mutations, including single nucleotide polymorphisms (SNPs) and copy number variants (CNVs).
Ruth M.A. Kouamé, Amy Lynd, Jackson K.I. Kouamé, Laura Vavassori, Kouabénan Abo, Martin J. Donnelly, Constant Edi, Eric Lucas   +7 more
doaj   +1 more source

Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus.

PLoS Genetics, 2021
Vector population control using insecticides is a key element of current strategies to prevent malaria transmission in Africa. The introduction of effective insecticides, such as the organophosphate pirimiphos-methyl, is essential to overcome the ...
Xavier Grau-Bové, Eric Lucas, Dimitra Pipini, Emily Rippon, Arjèn E van 't Hof, Edi Constant, Samuel Dadzie, Alexander Egyir-Yawson, John Essandoh, Joseph Chabi, Luc Djogbénou, Nicholas J Harding, Alistair Miles, Dominic Kwiatkowski, Martin J Donnelly, David Weetman, Anopheles gambiae 1000 Genomes Consortium   +16 more
doaj   +1 more source

Genetic Surveillance Reveals Differential Evolutionary Dynamic of Anopheles gambiae Under Contrasting Insecticidal Tools Used in Malaria Control

Molecular Ecology, Volume 35, Issue 5, March 2026.
ABSTRACT Malaria, a febrile disease caused by the Plasmodium parasites and transmitted by mosquitoes, is a leading cause of mortality in children under 5 in endemic countries. The widespread deployment of insecticide‐treated bed nets (ITNs) has significantly reduced malaria transmission, but rising levels of insecticide resistance threaten to halt the ...
Harun N. Njoroge, Lilian Namuli, Sanjay C. Nagi, Anastasia Hernandez‐Koutoucheva, Daniel P. McDermott, Erin Knight, Samuel Gonahasa, Amy Lynd, Ambrose Oruni, Catherine Maiteki‐Sebuguzi, Jimmy Opigo, Adoke Yeka, Agaba Katureebe, Mary Kyohere, Moses R. Kamya, Grant Dorsey, Janet Hemingway, Sarah G. Staedke, Chris Clarkson, Alistair Miles, Eric R. Lucas, Martin J. Donnelly   +21 more
wiley   +1 more source

Gene copy number and function of the APL1 immune factor changed during Anopheles evolution

Parasites & Vectors, 2020
Background The recent reference genome assembly and annotation of the Asian malaria vector Anopheles stephensi detected only one gene encoding the leucine-rich repeat immune factor APL1, while in the Anopheles gambiae and sibling Anopheles coluzzii, APL1
Christian Mitri, Emmanuel Bischoff, Karin Eiglmeier, Inge Holm, Constentin Dieme, Emma Brito-Fravallo, Abbasali Raz, Sedigheh Zakeri, Mahdokht I. K. Nejad, Navid D. Djadid, Kenneth D. Vernick, Michelle M. Riehle   +11 more
doaj   +1 more source

PoolSeq Genome‐Wide Association Studies and Microbial Signature Analyses Identify Novel Candidates Associated With Pyrethroid Resistance Evolution in Anopheles funestus in Cameroon

Molecular Ecology, Volume 35, Issue 1, January 2026.
ABSTRACT Intensification of insecticide resistance in malaria vectors is undermining efforts to sustain control strategies. The evolutionary features underlying such exacerbation in major vector such as Anopheles funestus are only partially understood.
Mahamat Gadji, Jonas A. Kengne‐Ouafo, Magellan Tchouakui, Murielle J. Wondji, Leon M. J. Mugenzi, Jack Hearn, Boyomo Onana, Charles S. Wondji   +7 more
wiley   +1 more source

Genetics and immunity of Anopheles response to the entomopathogenic fungus Metarhizium anisopliae overlap with immunity to Plasmodium

Scientific Reports, 2022
Entomopathogenic fungi have been explored as a potential biopesticide to counteract the insecticide resistance issue in mosquitoes. However, little is known about the possibility that genetic resistance to fungal biopesticides could evolve in mosquito ...
Tullu Bukhari, Vishukumar Aimanianda, Emmanuel Bischoff, Emma Brito-Fravallo, Karin Eiglmeier, Michelle M. Riehle, Kenneth D. Vernick, Christian Mitri   +7 more
doaj   +1 more source

Species Occurrence and Seasonal Variation of Malaria Vectors in Hadiya Zone, Ethiopia

BioMed Research International, Volume 2026, Issue 1, 2026.
Environmental change can alter the species occurrence and seasonal distribution of malaria vectors to higher altitudes and latitudes. Highlands remain dynamic due to factors that favor their growth and development. Invasive species have proliferated into new ecological niches, increased.
Anmut Assemie, Dasash Mulu, Eyerus Mekuriaw, Workineh Muluken, Syed Khurram Azmat   +4 more
wiley   +1 more source

Spatial Heterogeneity of CYP9K1 Gene Overexpression Driving Cross‐Resistance to Insecticide in Anopheles Mosquitoes Across Sub‐Saharan Africa: A Systematic Review and Meta‐Analysis

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Insecticide resistance in Anopheles mosquitoes poses a growing challenge to malaria elimination efforts across sub‐Saharan Africa, threatening the continued effectiveness of frontline interventions. Among the metabolic mechanisms driving resistance, the cytochrome P450 monooxygenase gene CYP9K1 has been increasingly associated with detoxification and ...
Obinna Chukwuemeka Nwinyi, Kehinde Favour Siyanbola, María Eugenia López-Arellano   +2 more
wiley   +1 more source

Molecular and entomological surveillance of malaria vectors in urban and rural communities of Benguela Province, Angola

Parasites & Vectors
Background Malaria is a major public health problem in Angola, with Anopheles gambiae sensu lato (s.l.) and An. funestus s.l. being the primary vectors. This study aimed to clarify the information gaps concerning local Anopheles mosquito populations. Our
Gonçalo Alves, Arlete Dina Troco, Gonçalo Seixas, Rebecca Pabst, Alfredo Francisco, Cani Pedro, Luzala Garcia, José Franco Martins, Sergio Lopes   +8 more
doaj   +1 more source

Larvicidal and Ovicidal Effects of Methanol Extracts From Selected Ethiopian Medicinal Plants Against Anopheles arabiensis and Aedes aegypti

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Background Synthetic insecticides face challenges, such as resistance, environmental damage, and harm to nontarget species, highlighting the need for alternative methods. Medicinal plants, along with their bioactive compounds, offer a promising solution. Objective This study investigated the efficacy of methanol extracts derived from traditionally used
Lensa Tesfaye, Esayas Aklilu, Ketema Tolossa, Abebe Animut, Zhengwei Huang   +4 more
wiley   +1 more source