Results 31 to 40 of about 227,453 (338)

Pancreatic Cancer‐Derived Extracellular Vesicles Enriched with miR‐223‐5p Promote Skeletal Muscle Wasting Associated with Cachexia

Advanced Science, EarlyView.
EVs and EV‐microRNAs (miRNAs) mediate PDAC‐skeletal muscle communication. miR‐223‐5p reduces METTL14 transcription by targeting MAFA, which subsequently decreases m6A methylation in skeletal muscles, ultimately leading to muscle wasting. This study highlights the absorption of miRNA in PDAC‐derived EVs by skeletal muscles and reveals a previously ...
Kangjing Xu, Rongxi Shen, Li Zhang, Xuejin Gao, Xinbo Wang, Changhua Zhang, Xi Chen, Xinying Wang   +7 more
wiley   +1 more source

Trastornos de la conducta alimentaria en adolescentes y jóvenes

Revista Médica Clínica Las Condes, 2012
Los Trastornos de la Conducta Alimentaria (TCA) son problemas relevantes de salud mental que afectan principalmente a mujeres adolescentes y jóvenes. En su etiología convergen factores biológicos, psicológicos y sociales y por lo tanto, el tratamiento ...
Gaete P. María Verínica, Dra., López C. Carolina, PS, Phd, Matamala B. Marcela, Dra.   +2 more
doaj   +1 more source

A Novel Theoretical Hypothesis on Comorbidity in the Elderly—The Disease of Sympathetic Overdrive (DSO)

AGING MEDICINE, EarlyView.
A novel hypothesis: The disease of sympathetic overdrive (DSO) as a unifying mechanism for comorbidity in the elderly. ABSTRACT The coexistence of multimorbidity and geriatric syndromes is a big character and role target to manage for the clinic works in older age, but related theories still require innovation and exploration.
Li Jie, Kong Jian, Yu Boxin, Li Hongyang
wiley   +1 more source

Psilocybin increases optimistic engagement over time: computational modelling of behaviour in rats

Translational Psychiatry
Psilocybin has shown promise as a novel pharmacological intervention for treatment of depression, where post-acute effects of psilocybin treatment have been associated with increased positive mood and decreased pessimism.
Elizabeth L. Fisher, Ryan Smith, Kyna Conn, Andrew W. Corcoran, Laura K. Milton, Jakob Hohwy, Claire J. Foldi   +6 more
doaj   +1 more source

The animal cachexia score (ACASCO)

Animal Models and Experimental Medicine, 2019
Background None of the published studies involving cancer cachexia experimental models have included a measure of the severity of the syndrome like the scoring system previously developed for human subjects.
Angelica Betancourt, Sílvia Busquets, Marta Ponce, Míriam Toledo, Joan Guàrdia‐Olmos, Maribel Peró‐Cebollero, Francisco J. López‐Soriano, Josep M. Argilés   +7 more
doaj   +1 more source

Preoperative Versus Postoperative Chemotherapy With CAPOX Plus Bevacizumab for Resectable Colorectal Liver Metastases: A Randomized Phase II Trial (HiSCO‐01)

Annals of Gastroenterological Surgery, EarlyView.
Our aim was to compare the outcomes of preoperative chemotherapy with postoperative chemotherapy in patients with resectable colorectal liver metastases treated with CAPOX‐Bev. We demonstrated that both preoperative and postoperative CAPOX‐Bev were safely administered, and preoperative chemotherapy showed a numerically higher treatment compliance rate ...
Yuji Takakura, Katsunori Shinozaki, Satoshi Ikeda, Hiroyuki Egi, Yuzo Hirata, Manabu Shimomura, Takafumi Oshiro, Takao Hinoi, Daisuke Sumitani, Masahiro Nakahara, Masanori Yoshimitsu, Naruhiko Honmyo, Tsuyoshi Kobayashi, Junko Tanaka, Hideki Ohdan, on behalf of the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)   +15 more
wiley   +1 more source

The Ghrelin-AgRP Neuron Nexus in Anorexia Nervosa: Implications for Metabolic and Behavioral Adaptations

Frontiers in Nutrition, 2020
Anorexia Nervosa (AN) is viewed as primarily a psychiatric disorder owing to the considerable behavioral and genetic overlap with mood disorders and other psychiatric traits.
Mathieu Méquinion, Claire J. Foldi, Zane B. Andrews   +2 more
doaj   +1 more source

Diagnostic reasoning in rehabilitation nutrition: Position paper by the Japanese Association of Rehabilitation Nutrition (secondary publication)

Journal of General and Family Medicine, 2022
Diagnostic reasoning is the thought process used to arrive at a diagnosis based on symptoms, examination findings, and laboratory values. Diagnosis is categorized as nonanalytic reasoning (intuition) and analytic reasoning (analysis).
Hidetaka Wakabayashi, Keisuke Maeda, Ryo Momosaki, Yoji Kokura, Yoshihiro Yoshimura, Dai Fujiwara, Shintaro Kosaka, Norio Suzuki   +7 more
doaj   +1 more source

Anorexia nervosa

Nature Reviews Disease Primers, 2015
Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. AN predominantly develops in adolescence in the peripubertal period. Without early effective treatment, the course is protracted with physical, psychological and social morbidity and high mortality.
Treasure, Janet, Zipfel, Stephan, Micali, Nadia, Wade, Tracey, Stice, Eric, Claudino, Angélica, Schmidt, Ulrike, Frank, Guido K., Bulik, Cynthia M., Wentz, Elisabet   +9 more
openaire   +4 more sources

Anorexia Nervosa and the Immune System—A Narrative Review

Journal of Clinical Medicine, 2019
The pathogenesis of an increasing number of chronic diseases is being attributed to effects of the immune system. However, its role in the development and maintenance of anorexia nervosa is seemingly under-appreciated.
Dennis Gibson, P. Mehler
semanticscholar   +1 more source