FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Resident Physician Perceptions of Wellness Interventions: A Single-Institution Qualitative Study. [PDF]
CureusCriscione J, Flodman K, Doolittle B.
europepmc +1 more source
Confidence Measurement Metrics in Multimodal Large Language Models for Ultrasound-Based Radiology Cases: Comparative Evaluation Study of Self-Reported, Consistency-Based, and Hybrid Methods. [PDF]
J Med Internet ResHan T, Shin J, Lee JH, Gu K.
europepmc +1 more source
Performance of DeepSeek V3, DeepSeek R1, ChatGPT 4o, and ChatGPT o1 on the National Health Professional and Technical Qualification Examination (Intermediate Level) in China: Comparative Analysis. [PDF]
JMIR Form ResXue J +5 more
europepmc +1 more source
Enhancing the capabilities of large language models for API calls through knowledge graphs. [PDF]
Sci RepYang Y, Xiao X, Yin P, Xie T, Ye Y.
europepmc +1 more source
A case study using sewage metagenomic data for assessment of text-to-SQL capabilities in large language models. [PDF]
Sci RepBecsei Á +6 more
europepmc +1 more source
Benchmarking large language models for genomic knowledge with GeneTuring. [PDF]
Brief BioinformShang X, Liao X, Ji Z, Hou W.
europepmc +1 more source
Looking back and to the future after four-plus years of language in chemistry.
Digit DiscovHocky GM, White AD.
europepmc +1 more source